A collage of some of the innovations

Innovations & Inventions

Explore many of the new technologies, potential treatments, unique research models, startup companies and organizations, and other innovations that Picower Institute faculty members have helped to introduce during their careers, working with collaborators ranging from mentors to students.

GENUS

A cartoon of microglia, stimulated by gamma waves, gobbling up amyloid plaque

IGF1

A schematic shows the role of IGF-1 in synaptic function

SCOUT

An organoid appears as an elongated, colorful, blob shape with large oblong holes in a few places

Open Ephys

A round circuit board labeled Open Ephys

TRAP

Stochastic electrotransport

EEG monitoring of anesthesia

Arbaclofen for Fragile X

Optical Quantal Imaging

Feedback-driven stimulation

A circuit diagram of the bandpass filter for feedback

Whole-brain tracking in moving animals

A white microscope with many wires and attachments sits on a black table

CuRVE & eFLASH

A saggital cross section of a mouse brain is richly stained in three distinct colors in three distinct areas: yellow in the very front and about halfway toward the back; green in a large area toward the front and cyan across wide areas, especially the cerebellum in the back

ELAST

Between a pair of two blue glvoes a shiny clear sheet of brain tissue is pulled taut

Genome-wide genetic screening in the mammalian brain

A scgenatuc showing how genetic material is loaded into viruses that are then injected into a mouse brain

Multi-color two-photon microscopy

A neuron shows synapses of different colors

miBrain

A miBrain stained in different colors looks like a tight tangle of many cells in a thick disk

SplitSage

CLARITY

A clarified brain with many different types of cells stained different colors

Huntington's Model Fruit Flies

Bright yellow wisps indicate aggregated mutant huntingtin protein.

Treating Amblyopia

A black and white close up photo of an eye

‘Pixelwise’ programmable image sensor

A composite of images features the whole imaging chip which includes a black rectangle in the top third labeled as the pixel area, a more orange below labeled as the amplifiers and analog digital converters and an outer area that contains the digital controls and readout. The whole chip is about 5 mm wide by 4 mm tall. An inset shows individual pixels, which are mostly a black photodiode with a thin strip on the left of smaller circuitry. A circuit schematic shows an arrangement of six pixel transistors.

Lab-engineered human blood-brain barrier

On a black backgound a 3D-looking loop of gray vessel is covered in green blotches

MAP

CyCLoPs

Four panels in a 2x2 array show a segment of intestine cross-sectioned in a deep blue. The left side shows when there is no bacteria and no cytokine response. On the right side there is bacteria and some of the tissue glows white. The bottom row of panels shows those areas zoomed in.

"Reanimation"

A slide shows EEG waves of a rat while awake, anesthetized and then reanimated with Ritalin

HDAC2 Inhibition

Schematics show HDAC2 and SP3 combining to inhibit memory

Orthogonal scanning microscope

Four panels show a neuron glowing in red and yellow. The top left panel shows a neurn looing pretty sharp. Below that are zoomed in sections also looking detailed. On the right is a neuron that looks hazy. Below that are zoomed in sections that are also clouded.

Deep in vivo molecular imaging

A microscope system, a complicated assemblage of optical, electronic and other equiptment built in several levels atop a metal table, is shielded around its side by dark paneling and copper colored screening.

SWITCH

A series of panels shows different things labeled with switch

Advanced Three-Photon Microscopy

A series of images shows a full vertical shaft of an organoid as well as slices at varying depths.

The p25 mouse

Slice through a mouse brain shows huge ventricles opened up by neurodegeneration in a p25 mouse

Altering circuits for mood disorders

Head silhouette with amygdala

GSK-alpha inhibitor for Fragile X

A series of black lines, mostly arrayed as three hexagons in a row, with letters H and N in chemically meaningful positions

Former Member Innovations and Inventions

View innovations and inventions by former Picower faculty