A very horizontal chart plots brain rhythm frequency over time with colors indicating power. Bars along the top indicate the dose of ketamine. After the dose starts more gamma frequency power appears. After the dose gets even higher, the gamma waves periodically stop and then resume.
May 20, 2024
Study models how ketamine’s molecular action leads to its effects on the brain
On a reddish background a minimalist cartoon head is shown in profile. Within the head is a graphic of four balls representing brain cells connecting into two balls that then both connect into just one.
May 13, 2024
How the brain is flexible enough for a complex world (without being thrown into chaos)
A little girl lies on a gray sofa under a blanket. A woman holds her gently with one hand and holds a thermometer in the girl's mouth with the other.
May 8, 2024
Autism symptoms sometimes improve amid fever, so a research team will study how to make that a therapy
A chart from a study plots bursts of brain waves of varying frequency at specific times. The bursts are represented as warm colors against a the blue background. When there are low frequency bursts there aren't high frequency bursts and vice versa.
April 23, 2024
In the brain, bursts of beta rhythms implement cognitive control
A black and white brain shown in profile is decorated with red light bulbs on its surface. In one spot, a stencil for making the light bulbs, labeled "beta," is present. Nearby is a can of red spray paint labeled "gamma" with a little wave on it.
April 17, 2024
Paper: To understand cognition—and its dysfunction—neuroscientists must learn its rhythms

Study models how ketamine’s molecular action leads to its effects on the brain

May 20, 2024
Research Findings
New research addresses a gap in understanding how ketamine’s impact on individual neurons leads to pervasive and profound changes in brain network function.

How the brain is flexible enough for a complex world (without being thrown into chaos)

May 13, 2024
Research Findings
Many neurons exhibit “mixed selectivity.” They can integrate multiple inputs and participate in multiple computations. Mechanisms such as oscillations and neuromodulators recruit their participation and tune them to focus on the relevant information.

Autism symptoms sometimes improve amid fever, so a research team will study how to make that a therapy

May 8, 2024
New Research
With support from The Marcus Foundation, an MIT neuroscientist and a Harvard Medical School immunologist will study the “fever effect” in an effort to devise therapies that mimic its beneficial effects.

In the brain, bursts of beta rhythms implement cognitive control

April 23, 2024
Research Findings
Bursts of brain rhythms with “beta” frequencies control where and when neurons in the cortex process sensory information and plan responses. Studying these bursts would improve understanding of cognition and clinical disorders, researchers write.

Paper: To understand cognition—and its dysfunction—neuroscientists must learn its rhythms

April 17, 2024
Research Findings
Thought emerges and is controlled in the brain via the rhythmically and spatially coordinated activity of millions of neurons, scientists argue in a new article. Understanding cognition and its disorders requires studying it at that level.

Tsai presents non-invasive stimulation study at Massachusetts Down Syndrome Congress

March 27, 2024
Picower Events
Alana Down Syndrome Center team recruiting volunteers to test whether 40Hz light and sound stimulation produces cognitive benefits.

Plasticity and place: Study shows a key neural mechanism of remembering locations

March 25, 2024
Research Findings
Scientists have now observed how the brain’s place cells stave off inhibitory input in the process of establishing their tuning to specific locations. The study shows that signaling by endocannabinoids is required.

Movement disorder ALS and cognitive disorder FTLD show strong molecular overlaps, new study shows

March 22, 2024
Research Findings
Single-cell gene expression patterns in the brain’s motor and frontal cortex, and evidence from follow-up experiments, reveal many shared cellular and molecular similarities that could be targeted for potential treatment

Livestreaming the Brain

March 15, 2024
Research Feature
To learn how the brain works, Picower Institute labs are advancing technologies and methods to watch it live as it happens

A noninvasive treatment for “chemo brain”

March 6, 2024
Research Findings
Stimulating gamma brain waves may protect cancer patients from memory impairment and other cognitive effects of chemotherapy, a new mouse study suggests.

How sensory gamma rhythm stimulation clears amyloid in Alzheimer’s mice

February 28, 2024
Research Findings
Stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer’s protein via the brain’s glymphatic system, new study suggests.

Study reveals a universal pattern of brain wave frequencies

January 18, 2024
Research Findings
Across mammalian species, brain waves are slower in deep cortical layers, while superficial layers generate faster rhythms.