A sequence of four panels on a black background shows colorful labeling of proteins, which appear as blue, purpole and green splotches. The left three panels show them independently. The right hand panel shows them all together.
January 13, 2022
Next-generation tissue expansion method improves neural imaging
Three bright yellow balls of cells appear in a row over a black background. The balls on each end have many litlle yellow projections raidating outward. The one in the middle has fewer projections and they aren't as long
January 6, 2022
In Down syndrome cells, genome-wide disruptions mimic a senescence-like state
A pregnant woman (face not shown) holds her belly with her right hand and a thermometer tilted toward her eyes with the left
December 7, 2021
Research finds potential mechanism linking autism, intestinal inflammation
Side by side cartoons show little balls descending toward a grayish carpet-like surface. The balls and carpets have colorful squiggles that sometimes connect
November 29, 2021
Study reveals a protein’s key contribution to heterogeneity of neurons
Neurons in a portion of a nematode worm glow in a microscope image on a black background
November 22, 2021
Feast or forage: Study finds circuit that helps a brain decide

Next-generation tissue expansion method improves neural imaging

January 13, 2022
Research Findings
An upgrade of ‘MAP’ enables labeling of more proteins, deeper studies of circuit junctions in brain tissue

In Down syndrome cells, genome-wide disruptions mimic a senescence-like state

January 6, 2022
Research Findings
Extra chromosome alters chromosomal conformation and DNA accessibility across the whole genome in neural progenitor cells, disrupting gene transcription and cell functions much like in cellular aging.

'Risky' Research

December 20, 2021
Research Feature
How bold new neuroscience research projects get off the ground

Research finds potential mechanism linking autism, intestinal inflammation

December 7, 2021
Research Findings
Moms infected during pregnancy who produce elevated levels of the cytokine IL-17a may have microbiome alterations that prime offspring for aberrant immune responses later in life, mouse study suggests

Study reveals a protein’s key contribution to heterogeneity of neurons

November 29, 2021
Research Findings
Tomosyn’s tight regulation of neurotransmitter release distinguishes functions of two neuron classes at the fly neuromuscular junction

Feast or forage: Study finds circuit that helps a brain decide

November 22, 2021
Research Findings
By integrating multiple sensory inputs, a loop of mutual inhibition among a small set of neurons allows worms to switch between long-lasting behavioral states

Young Picower scientists present projects at ‘SfN’

November 12, 2021
Picower People
Picower scientists shared research on brain waves, new technologies, brain plasticity and psychiatric illness and, of course, learning and memory.

Study links gene to cognitive resilience in the elderly

November 3, 2021
Research Findings
The findings may help explain why some people who lead enriching lives are less prone to Alzheimer’s and age-related dementia

Symposium spotlights crucial roles of dendrites

October 18, 2021
Recent Events
Scholars from around the world gathered online to share new research on how intricately structured neural processes enable plasticity of circuit connections and help integrate incoming information to enable brain function

NIH award funds innovative investigation of neurodegenerative motor diseases

October 5, 2021
New Research
Large-scale, integrated application of advanced computational, biological techniques aims to discover mechanisms underlying ALS and frontotemporal lobar degeneration with motor neuron disease

Study shows fragile X treatment can incur resistance, suggests ways around it

September 29, 2021
Research Findings
While the brain acquires resistance to continuous treatment with mGluR5 inhibitor drugs, lasting effects may still arise if dosing occurs intermittently and during a developmental critical period

'What Were you Thinking?'

September 20, 2021
Research Feature
How brain circuits integrate many sources of context to flexibly guide behavior