Disorders

Picower Institute scientists investigate the pathophysiological mechanisms underlying complex disorders of the brain that affect emotion and cognition. To learn more about research in these or other areas, select them under "Research Topics" and you'll find relevant Picower people, discoveries and events.

Mark Bear

Picower Professor of Neuroscience
Bear’s lab studies how experience and deprivation modify synaptic connections in the brain. Experience-dependent synaptic plasticity is the physical substrate of memory and sculpts connections during postnatal development to determine the capabilities and limitations of brain functions.

Emery N. Brown

Edward Hood Taplin Professor of Computational Neuroscience and Health Sciences & Technology
Brown lab research contributes to understanding the neuroscience of how anesthetics act in the brain to create the states of general anesthesia. Brown has developed signal processing algorithms to solve important data analysis challenges in neuroscience.

Steven Flavell

Assistant Professor of Neuroscience
Neural operations occur in milliseconds, yet the brain generates behaviors that can last hours. Flavell’s lab studies how neural circuits generate sustained behavioral states, and how physiological and environmental information is integrated into these circuits.

Michael Halassa

Assistant Professor, Department of Brain & Cognitive Sciences
Michael Halassa is a neuroscientist and psychiatrist who aims to understand the basic circuit mechanisms of how information is routed in the brain and how disruptions in these circuits can lead to neurological and psychiatric disorders.

Myriam Heiman

Latham Career Development Chair
Many neurodegenerative diseases begin with the loss of select groups of cells. Understanding select group vulnerability may help identify root causes and novel therapeutic targets. Heiman’s lab studies selective vulnerability and pathophysiology in Huntington’s and Parkinson’s diseases.

Troy Littleton

Menicon Professor in Neuroscience
Littleton studies how neurons form synaptic connections, how synapses transmit information, and how synapses change during learning and memory. The research combines molecular biology, protein biochemistry, electrophysiology, and imaging approaches with Drosophila genetics.

Earl K. Miller

Picower Professor of Neuroscience
Miller’s lab studies the neural mechanisms of attention, learning, and memory needed for voluntary, goal-directed behavior. The lab explores prefrontal function by employing a variety of techniques including multiple-electrode neurophysiology, psychophysics, pharmacological manipulations, and computational techniques.

Mriganka Sur

Newton Professor of Neuroscience
The goal of the Sur laboratory is to understand long-term plasticity and short-term dynamics in circuits of the developing and adult cortex, and to utilize this understanding to discover mechanisms underlying disorders of brain development.

Susumu Tonegawa

Picower Professor of Biology and Neuroscience
With cutting-edge neuroscience techniques, the Tonegawa lab unravels the molecular, cellular, and neural circuit mechanisms that underlie learning and memory. Studies bridge basic science and disease models to causally dissect how memory works and breaks down.

Li-Huei Tsai

Picower Professor of Neuroscience
The Tsai lab is interested in elucidating the pathogenic mechanisms underlying neurological disorders that impact learning and memory by taking a multidisciplinary approach to investigate the molecular, cellular, and circuit basis of neurodegenerative disorders.

Kay M. Tye

Associate Professor of Neuroscience
The Tye lab employs an interdisciplinary approach including optogenetics, electrophysiology, pharmacology and imaging techniques to find a mechanistic explanation for how emotional and motivational states can influence learning and behavior, in both health and disease.

Weifeng Xu

Assistant Professor of Neuroscience
The goal of the Xu Laboratory is to understand the mechanisms of neural plasticity essential for information processing and storage in the brain and their dysfunction in diseases such as autism, schizophrenia, bipolar disorder and intellectual disability.