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… Institute of Technology Research Areas mGluR5 , LTD , LTP , monocular deprivation , habituation , … a phenomenon called homosynaptic long-term depression (LTD). LTD is the functional inverse of long-term synaptic …

… a process called long-term depression. Bear’s lab showed LTD was real. “We found a protocol that elicited LTD,” Bear said. “That got the whole ball rolling on LTD and now there are 1,000s of papers.” LTD is enormously …

… the hippocampus, a region known for memory. That indicated LTD was a plasticity rule throughout the brain. In 2004 in Neuron, Bear’s lab, which had moved to MIT, showed that LTD of V1 neurons serving the deprived eye helped explain the … cortex synapses serving the deprived eye did not undergo LTD. MD models a common visual disorder called amblyopia in …

… can continue this work.” Original announcement Read more LTD , amblyopia , visual cortex , awards , development Print …

… Foundation funded the study. Research Article amblyopia , LTD , LTP , visual cortex , vision , cerebral cortex Print …

… synapses , inhibitory circuits , inhibitory neurons , LTD , LTP Print Share Related Articles Holding information in …

… Foundation. --From MIT News Research Article mGluR5 , LTD , autism , synapse function , Fragile X Syndrome Print …

… connections by a mechanism called long-term depression, or LTD. Subsequent studies in Bear’s Lab have led to potential therapies for disorders related to LTD. One is the common vision disorder amblyopia, in which … genetic loss of a protein called FMRP leads to too much LTD. His lab has discovered that intervening in the molecular …