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You searched for: ApoE

Study offers an explanation for why the APOE4 gene enhances Alzheimer’s risk

Wednesday, Mar 03
… supplements neurodegeneration Cellular and Molecular ApoE lipid metabolism … Julia Maeve Bonner. Lipid dysregulation The human gene for APOE, or apolipoprotein E, comes in three versions. While … and APOE3, the most common variant, is neutral. APOE is known to be involved in lipid metabolism, but its …
https://picower.mit.edu/node/763

Neuroscientists discover roles of gene linked to Alzheimer’s

Thursday, May 31
… However, little is known about why this version of the APOE gene, which is normally involved in metabolism and … (left) than the APOE3 tissue (right). Amyloid accumulation APOE, also called apolipoprotein E, comes in three variants, known as 2, 3, and 4. APOE binds to cholesterol and lipids in cells’ environments, …
https://picower.mit.edu/node/337

Study finds path for addressing Alzheimer’s blood-brain barrier impairment

Monday, Jun 08
… drugs could help stem cells iPSCs neurodegeneration ApoE https://www.nature.com/articles/s41591-020-0886-4 By … About 25 percent of people have the APOE4 variant of the APOE gene, which puts them at substantially greater risk for … variant, pericytes in their vessels churn out too much APOE protein, explained senior author Li-Huei Tsai , Picower …
https://picower.mit.edu/node/664

Alzheimer’s risk gene disrupts endocytosis, but another disease-linked gene could help

Tuesday, Oct 06
… the defect endocytosis astrocytes neurodegeneration ApoE … About 25 percent of people have the APOE4 variant of the APOE gene, which puts them at substantially greater risk for … gene called PICALM reversed the endocytosis defects. “Both APOE and PICALM are Alzheimer’s risk genes,” said Tsai, a …
https://picower.mit.edu/node/711

MIT sets out to model Alzheimer’s disease complexity on a chip

Thursday, Oct 03
https://picower.mit.edu/node/576

Human Models of Disease

Monday, Dec 16
… versions of the leading risk gene for Alzheimer’s disease, APOE. People with the APOE4 variant are at much higher risk … of the brain through the blood stream, so he can see how APOE variants affect that. Researchers are also looking at …
https://picower.mit.edu/node/598

Webinar: Lowering a Barrier to Understanding Alzheimer’s

https://picower.mit.edu/node/669

Genes & Disease

Monday, Dec 14
… biggest genetic risk factor, the APOE4 variant of the APOE gene.   Li-Huei Tsai As with autism spectrum disorders, …
https://picower.mit.edu/node/735

Dozens from Picower present research at SfN

Tuesday, Nov 13
https://picower.mit.edu/node/433

How could Covid-19 and the body’s immune response affect the brain?

Tuesday, Apr 21
… example, they study whether variations in a gene called ApoE causes different degrees of amyloid proteins plaque …
https://picower.mit.edu/node/637

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Massachusetts Institute of Technology
43 Vassar Street, Bldg. 46-1303
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(+1) 617-324-0305
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