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Study shows fragile X treatment can incur resistance, suggests ways around it

September 29, 2021

… the brain acquires resistance to continuous treatment with mGluR5 inhibitor drugs, lasting effects may still arise if … intermittently and during a developmental critical period mGluR5 Fragile X Syndrome autism spectrum disorders … the brain acquires resistance to continuous treatment with mGluR5 inhibitor drugs, lasting effects may still arise if …

Autism advances

June 16, 2025

… glutamate activates a neural receptor called mGluR5, spurring protein synthesis at the synapse. When Bear … neurological symptoms could be exaggerated responses to mGluR5 activation. Bear hypothesized that inhibiting protein … In 2007 his lab showed that genetically knocking down mGluR5 activity significantly improved many symptoms for …

Scientists find a new way to reverse symptoms of Fragile X

May 20, 2020

A molecular approach to autism

… that activation of a metabotropic glutamate receptor (mGluR5) triggers new protein synthesis in neurons that causes … loss of FMRP. In 2007 the Bear Lab showed that reducing mGluR5 expression by 50 percent significantly reduced a wide … elucidated the molecular mechanisms underlying the role of mGluR5 overactivity in fragile X symptoms and in 2012 the lab …

GSK-alpha inhibitor for Fragile X

… is stimulated by a neurotransmitter receptor called mGluR5. Normally, FMRP regulates this protein synthesis. When FMRP is lost in Fragile X, mGluR5-stimulated protein synthesis becomes overactive. Bear and others have found that compounds that inhibit the mGluR5 receptor can reverse most of the symptoms of Fragile X …

Findings weaken notion that size equals strength for neural connections

June 30, 2020

… to address Fragile X syndrome – by finding a “Protein X” mGluR5 synapse function synapse synapse formation synaptic … plasticity via two different neural receptors (called mGluR5 and NMDAR) under two different conditions … The first surprise of the study was that activating mGluR5 receptors induced the weakening, called long-term …

Mark Bear

… System Schizophrenia Neural Plasticity Learning and Memory mGluR5 LTD LTP monocular deprivation habituation potentiation … by activation of metabotropic glutamate receptor 5 (mGluR5) and requires immediate translation of mRNAs at … discovered that protein synthesis (and LTD) downstream of mGluR5 is exaggerated in the mouse model of fragile X (FX). …

Picower at Neuroscience 2021

… MIT, Cambridge, MA 2:30 PM - 3:30 PM Presentation P055.07 Mglur5 negative modulators for Fragile X: resistance and …

Genes & Disease

December 14, 2020

… Disease candidate plasticity genes Bipolar Disorder IGF1 mGluR5 CPG2 DNA’s resemblance to a twisted ladder provides an … receptor called metabotropic glutamate receptor 5, or mGluR5 . Activating mGluR5 causes synapses to weaken, a normal process called …