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Autism advances

June 16, 2025
… glutamate activates a neural receptor called mGluR5, spurring protein synthesis at the synapse. When Bear … neurological symptoms could be exaggerated responses to mGluR5 activation. Bear hypothesized that inhibiting protein … In 2007 his lab showed that genetically knocking down mGluR5 activity significantly improved many symptoms for …

A molecular approach to autism

… that activation of a metabotropic glutamate receptor (mGluR5) triggers new protein synthesis in neurons that causes … loss of FMRP. In 2007 the Bear Lab showed that reducing mGluR5 expression by 50 percent significantly reduced a wide … elucidated the molecular mechanisms underlying the role of mGluR5 overactivity in fragile X symptoms and in 2012 the lab …

Mark Bear

… System Schizophrenia Neural Plasticity Learning and Memory mGluR5 LTD LTP monocular deprivation habituation potentiation … by activation of metabotropic glutamate receptor 5 (mGluR5) and requires immediate translation of mRNAs at … discovered that protein synthesis (and LTD) downstream of mGluR5 is exaggerated in the mouse model of fragile X (FX). …

Genes & Disease

December 14, 2020
… Disease candidate plasticity genes Bipolar Disorder IGF1 mGluR5 CPG2 DNA’s resemblance to a twisted ladder provides an … receptor called metabotropic glutamate receptor 5, or mGluR5 . Activating mGluR5 causes synapses to weaken, a normal process called …
From: https://picower.mit.edu/search