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… Disorder Neuroimmune interactions anesthesia amygdala CPG2 Neuromodulators Picower Institute studies reveal a … Elly Nedivi's lab has linked low levels of the protein CPG2 to increased risk of bipolar disorder. Here they've … with bipolar disorder had lower levels in the brain of the CPG2 protein, a product of the SYNE1 gene which had been …

… improve diagnosis Bipolar Disorder synapse function CPG2 candidate plasticity genes plasticity genes plasticity … for Learning and Memory at MIT finds that the protein CPG2 is significantly less abundant in the brains of people … one and only.” The researchers are not suggesting that the CPG2-related variations in SYNE1 are “the cause” of bipolar …

… and synaptic function of two previously unknown CPGs: CPG2 and CPG15. In a study published earlier this year, her lab showed that the protein CPG2 is significantly less abundant in the brains of people … how specific mutations in the SYNE1 gene that encodes CPG2 undermine the protein’s expression and its function in …

… candidate plasticity genes Bipolar Disorder IGF1 mGluR5 CPG2 DNA’s resemblance to a twisted ladder provides an apt … of these variants which affect expression or function of CPG2, a key protein encoded by SYNE1, are sufficient to … you will develop the disease .”   Nedivi ’s lab discovered CPG2 while screening neurons for proteins whose expression …

… synapse disassembly plasticity genes CPG15 Neuritin CPG2 SYNE1 visual system In vivo cellular imaging inhibitory … and synaptic function of two previously unknown CPGs, CPG2 and CPG15, and characterized their very different … with multiple roles (also outside the nervous system), and CPG2 as a product of SYNE-1 , one of the best genetic hits …

… genetic susceptibility to bipolar disorder (BD) and CPG2 expression and function. CPG (Candidate Plasticity … work from the Nedivi lab found BD-related polymorphisms in CPG2 regulatory regions Kailong Wen Linlin Fan Wen is …

… During years of fundamental studies, Nedivi discovered CPG2, a protein expressed in response to neural activity that … receptors at excitatory synapses. The gene encoding CPG2 was recently identified as a risk gene for b ipolar d … people with bipolar disorder indeed had reduced levels of CPG2 because of variations in the SYNE1 gene . When they …