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… kinds of brain cells: neurons, microglia immune cells, and astrocytes. They edited some of the cells with CRISPR to make … including a big jump in cholesterol secretion by APOE4 astrocytes. Editing APOE4 cells to become APOE3 carriers … the problems, including the excess cholesterol in astrocytes. In several more studies over the next few years, …

… 45-75% for oligodendroglia of all cells or 19-40% for astrocytes.  The researchers developed the six cell types … of Alzheimer’s disease. Although one brain cell type, astrocytes, are known to be a primary producer of the APOE protein, the role that astrocytes carrying the APOE4 variant play in disease …