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In ‘minibrains,’ hindering key enzyme by different amounts has opposite growth effects

May 10, 2021
… can help improve organoid cultures, explain role of GSK3-beta in brain development organoids Rett syndrome autism … can help improve organoid cultures, explain role of GSK3-beta in brain development Like many around the world, the lab … the activity of a ubiquitous natural enzyme called GSK3-beta. In the new study in PLOS ONE the team led by Picower …

Making waves for health

March 01, 2018
… model mice to reduce the buildup of harmful amyloid beta proteins. The experiments reported in Nature showed that … from experiments in animals that a coordinated byplay of beta and gamma rhythms in the pre-frontal cortex (PFC) … the stored sensory information is needed for cognition. Beta rhythms, meanwhile, control when gamma is active and …

Brain waves and cognition

… care about circles”) were encoded within lower-frequency “beta” waves. The initial study concerned the role of these … across the cortex. Here we see that the peak frequency of beta rhythms increases as regions move from more basically … The Miller Lab’s work has shown that bursts of top-down beta waves from deep layers of the cortex typically govern …

As novel sights become familiar, different brain rhythms, neurons take over

June 08, 2021
… visual cortex. Gamma rhythms give way to lower frequency beta rhythms and the activity of PV neurons dies out in favor … diminished, replaced by a steady increase in low frequency beta power. To ensure this wasn’t an unrelated transition, on … the visual cortex reproduced the pattern of increased beta power. Experimental measurements show that high …

Anesthetic drastically diverts the travels of brain waves

April 27, 2022
… points as they do during consciousness. Higher frequency “beta” waves, meanwhile, became fewer and more erratically … are drastically altered by propofol,” Miller said. “The beta traveling waves seen during wakefulness are pushed … clear association between these two regimes (unfettered beta before or after anesthesia vs. delta dominance during …
From: https://picower.mit.edu/search