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… his studies of synapses. Caused by mutations in the gene MeCP2, Rett syndrome leads not only to autism symptoms but … Based on a 2007 paper that showed that shutting down the MeCP2 gene made mice sick, but even adolescent mice recovered … 2023. Sur has continued to publish studies revealing how MeCP2 mutations disrupt brain development. A 2017 study found …

… multiphoton imaging organoids minibrains Rett syndrome MECP2 neurodevelopmental disorders development … social behavior, is caused by mutations in the gene MECP2. To gain new insight into how the mutation affects the … organoids, or minibrains, using cells from people with MECP2 mutations and compared them to otherwise identical …

… girls develop abnormally because a mutant copy of the gene MeCP2 happens to be on one X chromosome they express. Her … X-chromosome silencing to express the healthy copy of MeCP2 on the inactivated X chromosome. Meanwhile speaker …

… to find that the disease-causing mutation in the gene MeCP2 led to misregulated forms of RNA that alter a key … on this work. Isogenic organoids with vs. without the MeCP2 mutation show distinct differences in development. They …

… disorder. The disease is caused by mutations in the gene MECP2. Sur’s lab showed that MECP2’s contribution to synaptic maturation comes via a … with extra IGF1 peptide or IGF1 corrected many defects of MECP2 mutation. Both treatment forms have advanced to …