March 10, 2023
3 questions for Mriganka Sur: The basic research origin of the first approved drug to treat Rett syndrome
… occurring in girls, caused by mutations in the gene MECP2 that leads to severe cognitive, motor and other … fragment could reverse the effects of reduced or altered MECP2. This provided a mechanism-based rationale for IGF-1 as … in Edinburgh made a mouse line in which they could keep MECP2 in check for the first 5 or 6 weeks of life, so that …