Li-Huei Tsai stands at a podium embossed with an MIT logo. In the foreground is an attentive audience. In the background is the Picower Institute logo
March 11, 2026
After 16+ years leading Picower Institute, Li-Huei Tsai will sharpen focus on research, teaching
Two panels show blue cells surrounded by thin green outlines. The outlines are much more consistent and prevalent in the image on the left, which is labeled as the wild type, than on the right which is labeled Rett syndrome.
February 25, 2026
In Rett syndrome, leaky brain blood vessels traced to microRNA
a series of small blocky spots of color appear in the aggregate to make up the shape of a worm as it stretches horizonally across a black background
February 24, 2026
As worms and jellyfish wriggle, new AI tools track their neurons
Linlin Fan stands in her lab with microscope equipment in the foreground.
February 17, 2026
Sloan Fellowship will help Fan advance technology to study how brain circuits change amid learning
Wearing white lab coats in the lab, Mark Bear stands behind Sara Kornfeld-Sylla as she sits in a stool at a lab bench
February 11, 2026
Fragile X study uncovers brainwave biomarker bridging humans and mice

Seemingly similar, two neurons show distinct styles as they interact with the same muscle partner

July 7, 2020
Research Findings
Diversity in how cells talk to the muscle they innervate reveal distinct propensities for change, or “plasticity”

Findings weaken notion that size equals strength for neural connections

June 30, 2020
Research Findings
Among study’s many surprises may be a new way to address Fragile X syndrome – by finding a “Protein X”

The story behind the science: How discovery develops

June 25, 2020
News Feature
An inside look at a key paper illustrates what it can take to publish new knowledge

‘Skyrocketing’ research by investing in young researchers

June 23, 2020
Picower People
Picower Institute postdocs advance new ideas, gain skills with support of NIH’s ‘K99’ awards

Dopamine signaling allows neural circuits to generate coordinated behaviors

June 11, 2020
Research Findings
As part of study, team invents new open-source microscopy platform

Study finds path for addressing Alzheimer’s blood-brain barrier impairment

June 8, 2020
Research Findings
MIT researchers pinpoint mechanism and demonstrate drugs could help

Like a treasure map, brain region emphasizes reward location

June 1, 2020
Research Findings
Lateral septum encodes spatial information with a special emphasis on where the reward lies

Closing social distance with social media by highlighting a volunteer science movement

May 29, 2020
News Feature
While home from the bench, Tonegawa lab postdoc co-runs Twitter feed of the Covid-19 National Scientist Volunteer Database

McKnight Scholars Award supports Flavell lab’s gut-brain connection studies

May 28, 2020
Picower People
Award will help researchers understand how the body’s microbiome influences the brain

Research highlights immune molecule’s complex role in Huntington’s disease

May 26, 2020
Research Findings
Knocking out the immune cytokine IL-6 exacerbates symptoms in HD model mice, affects neural connection genes

Grant fuels effort to develop new Alzheimer’s drug

May 22, 2020
New Research
Collaboration will develop compound to correct gene expression in brain’s immune cells

Scientists find a new way to reverse symptoms of Fragile X

May 20, 2020
Research Findings
Drug compound, tested in mice, could be effective in treating the leading heritable cause of intellectual disability and autism