Li-Huei Tsai stands at a podium embossed with an MIT logo. In the foreground is an attentive audience. In the background is the Picower Institute logo
March 11, 2026
After 16+ years leading Picower Institute, Li-Huei Tsai will sharpen focus on research, teaching
Two panels show blue cells surrounded by thin green outlines. The outlines are much more consistent and prevalent in the image on the left, which is labeled as the wild type, than on the right which is labeled Rett syndrome.
February 25, 2026
In Rett syndrome, leaky brain blood vessels traced to microRNA
a series of small blocky spots of color appear in the aggregate to make up the shape of a worm as it stretches horizonally across a black background
February 24, 2026
As worms and jellyfish wriggle, new AI tools track their neurons
Linlin Fan stands in her lab with microscope equipment in the foreground.
February 17, 2026
Sloan Fellowship will help Fan advance technology to study how brain circuits change amid learning
Wearing white lab coats in the lab, Mark Bear stands behind Sara Kornfeld-Sylla as she sits in a stool at a lab bench
February 11, 2026
Fragile X study uncovers brainwave biomarker bridging humans and mice

Alzheimer’s risk gene disrupts endocytosis, but another disease-linked gene could help

October 6, 2020
Research Findings
Astrocytes with the APOE4 variant show deficits of key cellular function, but overexpressing PICALM overcame the defect

Neuroscientists discover a molecular mechanism that allows memories to form

October 5, 2020
Research Findings
Modifications to chromosomes in “engram” neurons control the encoding and retrieval of memories

Statistical model improves analysis of skin conductance

October 5, 2020
Research Findings
By accounting for sweat physiology, method can make better use of electrodermal activity for tracking subconscious changes in physical or emotional state

Symposium highlights numerous leads to combat neurodegeneration

September 24, 2020
Recent Events
In 10 talks, leading neuroscientists shared potential advances against Alzheimer’s, Parkinson’s, Huntington’s and other diseases

Picower researcher earns BBRF Young Investigator grant

September 21, 2020
Picower People
Sur Lab postdoc Vincent Breton-Provencher will use award to study neurobiology underlying attention

From Biological Intelligence to Artificial Intelligence

September 17, 2020
Research Feature
How basic neuroscience research by Picower faculty has mattered to AI

Live imaging method brings structural information to mapping of brain function

September 17, 2020
Research Findings
Scientists distinguish brain regions based on what they do, but now have a new way to overlay information about how they are built

As information flows through brain’s heirarchy, higher regions use higher frequency waves

September 8, 2020
Research Findings
Study also finds specific frequency bands associated with encoding, or inhibiting encoding, of sensory information across the cortex

New trial to test brain wave stimulation as Alzheimer’s preventative

August 25, 2020
New Research
MIT, MGH join forces to test whether ‘GENUS’ stimulation of 40Hz rhythms can reduce disease pathology before onset of symptoms

Math shows how brain stays stable amid internal noise and a widely varying world

August 10, 2020
Research Findings
Theoretical framework shows that many properties of neural connections help biological circuits produce consistent computations

To distinguish contexts, animals think probabilistically, study suggests

August 3, 2020
Research Findings
A new statistical model may help scientists understand how animals make inferences about whether their surroundings are novel or haven’t changed enough to be a new context

Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA

July 17, 2020
Research Findings
Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons