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… occur as “electrographic seizures” which are bursts of voltage among neurons across a broad spectrum of frequencies. …

… is an especially effective blocker. Blocking slows the voltage build-up across the neuron’s membrane that eventually … other neurons. The NMDA doorway becomes unblocked when the voltage gets high. This interdependence between voltage, spiking and blocking can equip NMDA receptors with …

… watch it live as it happens multiphoton microscopy calcium imaging In vivo cellular imaging voltage imaging all-optical physiology To learn how the brain … neural electrical activity, called Genetically Encoded Voltage Indicators, or GEVIs. Among them are new Picower …

… measurements. Those measures track the rapid voltage changes, or spikes, that neurons exhibit as they … quickly the waveform ranges between its lowest and highest voltage (“trough to peak duration”), and how quickly the voltage changes again afterward, returning from the peak to …

… with Rod MacKinnon to define the structural basis for voltage-sensing in voltage-dependent ion channels. During her post-doctoral …