… decided to explore the role of sirtuins in endothelial cells, which line the inside of blood vessels. To do that, … which encodes the major mammalian sirtuin, in endothelial cells of mice. They found that at 6 months of age, these mice … Vittorio Sartorelli, chief of the Laboratory of Muscle StemCells and Gene Regulation at the National Institute of …
… new insights into the nature of diseases that cause brain cells to die, but also described promising new treatment … potential treatment for Parkinson’s disease in which brain cells called astrocytes can be converted into neurons in a … mice, negatively impacting the proliferation of neural stemcells and therefore their ability to produce new neurons …
… more fundamental understanding of the biology going on in cells of people with Down syndrome, often also called trisomy … in the lab is by engineering human cell cultures from cells taken from patients. Skin cells, for instance, can be turned into stemcells, which in turn can grow into neurons or heart …
… how a genetic aberration undermines the function of brain cells and circuits . Learning how things go wrong puts within … survive the disease. The gene, as it turns out, may help cells dispose of protein a ggregates (such as mutant … vs. the more common APOE3 version. In 2018, they used stemcells derived from patients’ skin cells to create …