Saturday, Oct. 19, 2019
Session 44 Cellular and Circuit Mechanisms in Tauopathies
4:00 PM - 5:00 PM
Presentation 044.04 / D7 Neuronal hyperactivity and DNA damage in tau P301S mouse model
*L. LIU, P.-C. PAO, L. A. WATSON, L.-H. TSAI;
MIT, Cambridge, MA
Session 74 Fear and Aversive Learning and Memory: Extinction
2:00 PM - 3:00 PM
Presentation 074.02 / U12 Amygdala reward neurons form and store fear extinction memory
*X. ZHANG1, J. KIM2, S. TONEGAWA3;
1Dept. of Brain and Cognitive Sci., MIT. The Picower Inst. for Learning and Memory, Cambridge, MA; 2Dept. of Brain and Cognitive Sci., Cambridge, MA; 3The Picower Inst. for Learning and Memory, MIT, Cambridge, MA
Session 81 Network Activity
4:00 PM - 5:00 PM
Presentation 081.20 / X38 Achieving and using stability in neural circuits
*L. KOZACHKOV1, M. LUNDQVIST1, J.-J. SLOTINE2, E. K. MILLER1;
1Brain and Cognitive Sci., 2Mechanical Engineering, Brain and Cognitive Sci., MIT, Cambridge, MA Display Abstract
Sunday, Oct. 20, 2019
Session 113 Postnatal Neurogenesis
9:00 AM - 10:00 AM
Presentation 113.26 / A26 Altered 3D-Genome Architecture of Neural Progenitor Cells as a Consequence of Down Syndrome
*H. MEHARENA1, L.-H. TSAI2;
1MIT, Cambridge, MA; 2The Picower Inst. for Learning and Memory, MIT, Cambridge, MA
Session 175 Drug Delivery
8:00 AM - 12:00 PM
Presentation 175.11 / DP14/BB81 A non-human primate model for closed-loop control of propofol-induced unconsciousness
*S. CHAKRAVARTY1, J. A. DONOGHUE2, A. WAITE1, M. K. MAHNKE1, I. C. RICE3, E. K. MILLER1, E. N. BROWN4;
1Picower Inst. for Learning and Memory, 2Brain and Cognitive Sci., 3Harvard-MIT Hlth. Sci. and Technol. Program, 4MIT, Cambridge, MA
Session 244 Hippocampus and Cognition
4:00 PM - 5:00 PM
Presentation 244.08 / X37 Hippocampal circuit mechanisms encoding experience as abstract, ordered, and transferable chunks
*C. SUN1, W. YANG3, J. MARTIN1, S. TONEGAWA2;
2The Picower Inst. for Learning and Memory, 1MIT, Cambridge, MA; 3Neurosci., NYU, New York, NY
Monday, Oct. 21, 2019
Session 278 Pluripotent Stem Cells and Organoid Models of Degenerative Diseases
10:00 AM - 11:00 AM
Presentation 278.19 / A61 Engineering human cerebral organoid as a model for studying Down syndrome
*Y.-T. LIN1, J. DAVILA2, H. MATHYS1, H. WOOLF1, H. CAM1, C. YU1, L.-H. TSAI1;
1Picower Inst. for Learning and Memory, 2Broad Inst., MIT, Cambridge, MA
Session 292 Alzheimer's Disease: Omics Approaches
11:00 AM - 12:00 PM
Presentation 292.16 / E26 Chronic gamma entrainment induces a persistent neuroprotective state in mouse model of neurodegeneration
C. ADAIKKAN, A. MARCO, *K. ABDELAAL, L.-H. TSAI;
Picower Inst. for Learning and Memory, MIT, Cambridge, MA
Session 293 Synaptic Dysfunction in Alzheimer's Disease: In Vivo Models II
9:00 AM - 10:00 AM
Presentation 293.10 / F4 Investigating the roles of Papez circuit in health and Alzheimer’s disease
*W.-C. HUANG1, L. LIU1, H. MATHYS1, Z. PENG1, F. GAO1, L.-H. TSAI1,2;
1The Picower Inst. for Learning and Memory, Dept. of Brain and Cognitive Sci., MIT, Cambridge, MA; 2Broad Inst. of MIT and Harvard, Cambridge, MA
Session 331 Attention
10:00 AM - 11:00 AM
Presentation 331.07 / AA9 Locus coeruleus stimulation averts stress-induced attentional deficits and anxiety
*A. BARI1,2, S. XU1,2, J. MARTIN1,2, S. TONEGAWA1,3,2;
1The Picower Inst. for Learning and Memory, Dept. of Brain and Cognitive Sci., 2RIKEN-MIT Ctr. for Neural Circuit Genet., 3Dept. of Biol., MIT, Cambridge, MA
Session 261 Artificial Intelligence and Neuroscience: From Neural Dynamics to Artificial Agents
8:35 AM - 8:55 AM
Presentation 261.02 Understanding neural dynamics under flexible visuomotor tasks with neural decoding and manifold learning
O. COSTILLA REYES
Massachusetts Institute of Technology, Boston, MA
Session 352 Genetic Models for Autism Spectrum Disorders
2:45 PM - 3:00 PM
Presentation 352.08 Visual recognition memory as a translational biomarker of genetically defined autism spectrum disorders
*P. S. B. FINNIE1, L. J. PIERCE2, E. S. KAPLAN4, M. LEE5, S. F. COOKE6, C. A. NELSON3, M. F. BEAR1;
1Picower Inst. of Learning and Memory, MIT, Cambridge, MA; 2Boston Children's Hosp., 3Richard David Scott Chair in Pediatric Developmental Med. Res., Harvard Med. Sch., Boston, MA; 4Seattle Children's Res. Inst., Seattle, WA; 5Wellesley Col., Wellesley, MA; 6Dept. of Basic and Clin. Neurosciences, King's Col. London, London, United Kingdom
Session 366 Genetic and Neural Mechanisms for Development Disorders
2:00 PM - 3:00 PM
Presentation 366.18 / A75 Understanding and overcoming pharmacological tolerance in the treatment of fragile-X syndrome
*P. K. MCCAMPHILL1, R. K. SENTER1, H. J. DE JESÚS-CORTÉS1, M. F. BEAR2;
1Picower Inst. for Learning and Memory, 2MIT, Cambridge, MA
Session 378 Neurodegenerative Disorders and Injury II
4:00 PM - 5:00 PM
Presentation 378.08 / D40 Neuronal DNA double strand breaks in the CK-p25 mouse model of severe neurodegeneration
*G. M. WELCH1, J. D. CHENG1, Q. SU2, M. KELLIS1, A. PFENNING2, L.-H. TSAI1;
1The Picower Inst. for Learning and Memory, MIT, Cambridge, MA; 2Carnegie Mellon Univ., Pittsburgh, PA
Tuesday, Oct. 22, 2019
Session 464 Cellular Mechanisms of Oscillations
8:00 AM - 9:00 AM
Presentation 464.17 / B81 Differences in thalamocortical synchronization during sleep and anesthesia-induced unconsciousness
*J. B. BRISCOE1,2, J. HARROD2, M. A. WILSON2, P. L. PURDON1, E. N. BROWN1,2, F. J. FLORES1,2;
1Anesthesia, Critical Care and Pain Med., Massachusetts Gen. Hosp., Boston, MA; 2The Picower Inst. of Learning and Memory, Dept. of Brain and Cognitive Sci., MIT, Cambridge, MA
9:00 AM - 10:00 AM
Presentation 464.18 / B82 A tale of two alpha oscillations: Spatially coherent alpha dynamics during propofol-induced unconsciousness reflect functional organization of thalamocortical connections
*P. KAHALI1, V. S. WEINER2, D. W. ZHOU2, E. P. STEPHEN3, L. D. LEWIS1, R. A. PETERFREUND5, L. S. AGLIO5, E. N. ESKANDAR6, S. S. CASH8, E. N. BROWN4, P. L. PURDON7;
1Picower Inst. for Learning and Memory, 2Dept. of Brain and Cognitive Sci., 3Inst. of Med. Engin. and Sci., 4MIT, Cambridge, MA; 5Anesthesia, Critical Care and Pain Med., 6Massachusetts Gen. Hosp., Boston, MA; 7Anesthesia, Critical Care, and Pain Mgmt., Massachusetts Gen. Hosp., Charlestown, MA; 8Dept Neurol, Mass Genl Hosp, Boston, MA
Session 490 Visual Learning, Memory, and Categorization
10:00 AM - 11:00 AM
Presentation 490.07 / N4 Temporal expectation in marmosets
*T. DRAGOI1, H. SUGIHARA1, M. HU1, J. SHARMA1, M. SUR2;
1Picower Inst. for Learning and Memory, 2Dept. of Brain and Cognitive Sci., MIT, Cambridge, MA Display Abstract
Session 520 Molecular Structural Imaging
8:00 AM - 9:00 AM
Presentation 520.01 / CC3 Non-parametric hyperdimensional analysis of multiscale phenotypic factors in intact cerebral organoids
*J. SWANEY1, A. ALBANESE2, D. YUN2, N. EVANS3, L. KAMENTSKY4, M. KIM4, C. SOHN4, J. ANTONUCCI-JOHNSON4, V. PHAM4, C. DELEPINE5, M. SUR5, L. GEHRKE4, K. CHUNG5;
1Dept. of Chem. Engin., 2Inst. for Med. Engin. and Sci., 3Picower Inst. for Learning and Memory, 5Dept. of Brain and Cognitive Sci., 4MIT, Cambridge, MA
8:00 AM - 12:00 PM
Presentation 520.04 / DP13/CC6 Ultrafast brain-wide immunostaining for scalable single-cell-resolution proteomic phenotyping
*D. YUN1,2, Y.-G. PARK1,2, J. H. CHO3, L. KAMENTSKY1, N. EVANS1, K. XIE1, A. ALBANESE1, J. SWANEY3, Y. TIAN3, C. SOHN1, W. GUAN3, G. DRUMMOND2, H. CHOI1, T. KU1, Q. ZHANG2,4, H.-Y. JUNG1, L. RUELAS3, G. FENG2,4, K. CHUNG1,2,5,3,6;
1Inst. for Med. Engin. and Sci., 2Dept. of Brain and Cognitive Sci., 3Dept. of Chem. Engin., 4McGovern Inst. for Brain Res., 5Picower Inst. for Leaning and Memory, MIT, Cambridge, MA; 6Broad Inst. of Harvard Univ. and MIT, Cambridge, MA
8:00 AM - 9:00 AM
Presentation 520.05 / CC7 Mechanical interlocking of biomolecules in situ preserves tissue architecture and integrity of biomolecules
*Y. TIAN1, J. T. MARTIN2, X. JIN8,3, D. J. IRVINE4,2,9,5,10, K. CHUNG1,8,3,6,7;
1Chem. Engin., 2Koch Inst. for Integrative Cancer Res., 3Inst. for Med. Engin. and Sci., 4Biol. Engin., 5Material Sci. and Engin., 6Picower Inst. for Learning and Memory, 7Brain and Cognitive Sci., MIT, Cambridge, MA; 8Broad Inst. of Harvard Univ. and MIT, Cambridge, MA; 9Ragon Inst. of Massachusetts Gen. Hospital, Massachusetts Inst. of Technol. and Harvard Univ., Cambridge, MA; 10Howard Hughes Med. Inst., Chevy Chase, MD
9:00 AM - 10:00 AM
Presentation 520.02 / CC4 An engram index permits brain-wide mapping of a specific memory
D. S. ROY1, *Y.-G. PARK1, S. K. OGAWA1, J. CHO1, H. CHOI1, J. MARTIN1, K. CHUNG2,1, S. TONEGAWA1,2;
1The Picower Inst. for Learning and Memory, 2Brain and Cognitive Sci., MIT, Cambridge, MA
9:00 AM - 10:00 AM
Presentation 520.06 / CC8 SHIELD protocols for scalable tissue protection and imaging
*K. XIE1,2, S. CHOI3, H. AHN5, Y.-G. PARK1,2, C. SOHN1,2, D. YUN1,2, N. EVANS1,2, E. NICHOLS6, K. SAIJO6, K. CHUNG4,2,3,1,7;
1Inst. for Med. Engin. and Sci., 2Picower Inst. for Learning and Memory, 3Dept. of Chem. Engin., 4Dept. of Brain and Cognitive Sci., MIT, Cambridge, MA; 5Yonsei-IBS Inst., Yonsei Univ., Seoul, Korea, Republic of; 6Dept. of Mol. and Cell Biol., Univ. of California Berkeley, Berkeley, CA; 7Broad Inst. of Harvard Univ. and MIT, Cambridge, MA
10:00 AM - 11:00 AM
Presentation 520.03 / CC5 Multiplexed organ-wide mapping of biomolecules using oligonucleotide labeling
*C. H. SOHN1,2, Y. TIAN3,2, M. E. KIM1,2, N. P. TOWNSEND HASS3,2, L. DELORENZO1,2, K. CHUNG1,2,3,4;
1Inst. of Med. Engin. and Sci., 2Picower Inst. of Learning and Memory, 3Chem. Engin., MIT, Cambridge, MA; 4Broad Inst. of MIT and Harvard, Cambridge, MA
10:00 AM - 11:00 AM
Presentation 520.07 / CC9 A scalable pipeline for comprehensive single-cell resolution mapping of the human brain
*W. GUAN1, T. KU2,3, N. EVANS2,3, Y.-G. PARK2,3, C. SOHN2,3, D. YUN2,3, J. WANG5, S.-C. CHEN5, M. FROSCH6, K. CHUNG1,2,3,4,7;
1Chem. Engin., 2Picower Inst. for Learning and Memory, 3Inst. for Med. Engin. and Sci., 4Brain and Cognitive Sci., MIT, Cambridge, MA; 5Mechanical and Automation Engin., Chinese Univ. of Hong Kong, Shatin, Hong Kong; 6C.S. Kubik Lab. for Neuropathology, Massachusetts Gen. Hosp. and Harvard Med. Sch., Boston, MA; 7Broad Inst. of Harvard Univ. and MIT, Cambridge, MA
11:00 AM - 12:00 PM
Presentation 520.08 / CC10 Scalable cell phenotyping framework for microglial cells
*M. E. KIM1,2, G. DRUMMOND2, E. NICHOLS5, N. B. EVANS1, Y.-G. PARK1, N. DINAPOLI1, D. YUN1,2, K. XIE1, J. SWANEY3, K. SAIJO5, K. CHUNG2,3,1,4;
1Inst. for Med. Engin. and Sci., 2Dept. of Brain and Cognitive Sci., 3Dept. of Chem. Engin., 4Picower Inst. for Learning and Memory, MIT, Cambridge, MA; 5Dept. of Mol. Cell Biol., Univ. of California Berkeley, Berkeley, CA
Session 439 Beta Oscillations in Sensorimotor Function, Executive Action Control, and Working Memory
8:35 AM - 8:55 AM
Presentation 439.02 An inhibitory role of cortical beta in working memory control and clear out
M. Lundqvist;
MIT Picower Institute for Learning and Memory, Massachussetts Institute of Technology, Cambridge, MA.
Session 443 Special Lecture- Leveraging Brain Rhythms as a Therapeutic Intervention for Neurodegenerative Diseases
Hall B
12:00 PM - 1:10 PM
Presentation 443 Leveraging brain rhythms as a therapeutic intervention for neurodegenerative diseases
*L.-H. TSAI;
Picower Inst. Learning and Memory, MIT, CAMBRIDGE, MA
Session 564 Alzheimer's Disease and Other Dementias: Therapeutic Strategies III
3:00 PM - 4:00 PM
Presentation 564.07 / E26 A novel Cdk5 inhibitory peptide attenuates pathological features in human and mouse models of Alzheimer's disease
*O. KRITSKIY1, J. SEO2, L.-H. TSAI3;
1Picower Inst. for Learning and Memory, 2Picower Inst. for Learning and Memory, Brain and Cognitive Sci., MIT, Cambridge, MA; 3The Picower Inst. for Learning and Memory, MIT, Cambridge, MA
Session 576 Visual System: Response Modulation and Adaptation
4:00 PM - 5:00 PM
Presentation 576.12 / J37 Cellular representation of visual recognition memory in the mouse primary visual cortex
*T. KIM1, M. T. HARNETT2, M. F. BEAR1;
1Picower Inst. for Learning and Memory, 2Mcgovern Inst. for Brain Res., MIT, Cambridge, MA
Session 577 Visual Pathways: To and From the Cortex
4:00 PM - 5:00 PM
Presentation 577.08 / K7 Identifying neural circuits underlying visually evoked entrainment
*C. ADAIKKAN1, K. ABDELAAL1, M. MURDOCK1, A. J. HUANG3, H. A. SULLIVAN2, I. WICKERSHAM2, T. J. MCHUGH3, L.-H. TSAI1;
1Picower Inst. for Learning and Memory, 2McGovern Inst. for Brain Res., MIT, Cambridge, MA; 3RIKEN Ctr. for Brain Sci., Wako, Japan
Session 583 Cortical Planning and Execution: Neurophysiology in Rodents and Others II
1:00 PM - 2:00 PM
Presentation 583.05 / M34 A new interpretation of visual cortical areas in mice
*M. HU1, R. V. RIKHYE2, M. GOARD3, M. G. M. KUMAR4, H. MURTHY4, M. SUR1;
1Picower Inst. for Learning and Memory, Cambridge, MA; 2Vicarious AI, San Francisco, CA; 3Molecular, Cell. and Developmental Biol. / Psychological & Brain Sci., Univ. of California, Santa Barbara, Santa Barbara, CA; 4Indian Inst. of Technol., Madras, India
1:00 PM - 2:00 PM
Presentation 583.09 / M38 Modulation of neuronal coding by astrocytes during motor learning
C. DELEPINE1, *K. LI1, V. SHAH2, T. JOHNS1, M. SUR3,1;
1Picower Inst. for Learning and Memory, 2Biol. Engin., 3Dept. of Brain and Cognitive Sci., MIT, Cambridge, MA
2:00 PM - 3:00 PM
Presentation 583.06 / M35 Involvement of the locus coeruleus network in an attention-demanding sensory discrimination task
*V. BRETON-PROVENCHER, M. SUR;
Brain and Cognitive Sciences, Picower Inst. For Learning and Memory, MIT, Cambridge, MA
3:00 PM - 4:00 PM
Presentation 583.07 / M36 Prefrontal cortex-superior colliculus interactions during visually guided decision-making
R. HUDA, *K. G. CRUZ, A. SULLINS, M. SUR;
Dept. of Brain and Cognitive Sci., MIT, Cambridge, MA
4:00 PM - 5:00 PM
Presentation 583.08 / M37 Dynamic control of visually-guided locomotion through cortico-subthalamic projections
*E. M. ADAM, T. JOHNS, M. SUR;
Picower Inst. For Learning and Memory, MIT, Cambridge, MA
Session 601 Neural Circuits for Learning and Memory
2:00 PM - 3:00 PM
Presentation 601.06 / Y24 Cortical and subcortical information processing during a context-association task
*M. MOAZAMI GOUDARZI, E. K. MILLER;
MIT, Cambridge, MA
Session 605 Cortical Oscillations II
1:00 PM - 2:00 PM
Presentation 605.21 / BB1 Coherent alpha dynamics during recovery from traumatic coma detected using global coherence analysis
*D. W. ZHOU1, C. CHATELLE2, E. N. BROWN1, B. L. EDLOW3;
1Brain and Cognitive Sci., MIT, Cambridge, MA; 2Neurol., Univ. Hosp. of Liège, Liège, Belgium; 3Neurol., Massachusetts Gen. Hosp., Boston, MA
3:00 PM - 4:00 PM
Presentation 605.19 / AA43 Testing the mechanisms of cortical fragmentation with propofol induced loss of consciousness and large scale cortical recordings in the non human primate
*A. M. BASTOS, J. DONOGHUE, C. SHVARTSMAN, J. YANAR, M. LUNDQVIST, J. TAUBER, M. MAHNKE, A. WAITE, E. N. BROWN, E. K. MILLER;
MIT, Cambridge, MA
4:00 PM - 5:00 PM
Presentation 605.20 / AA44 Thalamic stimulation reverses GABAergic but not anti-glutamatergic general anesthesia in monkeys
J. A. DONOGHUE1,2,3, *J. YANAR1, M. M. KOWALSKI4, S. KORNBLITH1, M. K. MAHNKE2, M. LUNDQVIST2, J. E. ROY2, A. BASTOS2, N. J. KOPELL5, E. N. BROWN2,3, E. K. MILLER2;
1Brain & Cognitive Sci., 2Picower Inst. for Learning and Memory, MIT, Cambridge, MA; 3Hlth. Sci. and Technol., Harvard Med. Sch., Cambridge, MA; 4Dept. of Mathematics and Statistics, 5Boston Univ., Boston, MA
Wednesday, Oct. 23, 2019
Session 642 Autism: Neurons, Circuits, and Behavior
9:00 AM - 10:00 AM
Presentation 642.10 / A81 Modulation of ASD-like behavior in the MIA mouse model
*M. D. REED1, S. KIM2, Y. YIM1, H. KIM2, H. KING1, G. WELCH1, M. T. HARNETT3, A. WAISMAN4, L.-H. TSAI1, J. H. HUH2, G. B. CHOI1;
1The Picower Inst. for Learning and Memory, MIT, Cambridge, MA; 2Immunol., Harvard Med. Sch., Boston, MA; 3MIT, Cambridge, MA; 4Inst. for Mol. Med., Univ. Med. Ctr. of the Johannes Gutenberg-University Mainz, Mainz, Germany
Session 692 Oscillations
8:00 AM - 9:00 AM
Presentation 692.21 / Y35 Correlates of behavioral flexibility within the frontal cortex of the macaque during categorization
*R. LOONIS, E. K. MILLER;
Picower Inst. for Memory and Learning, MIT, Cambridge, MA
10:00 AM - 11:00 AM
Presentation 692.23 / Y37 Are oscillatory correlates of working memory preserved across cortex?
*M. LUNDQVIST, A. M. BASTOS, E. K. MILLER;
Picower Inst. of Learning and Memory, Massachussetts Inst. of Technol., Cambridge, MA
11:00 AM - 12:00 PM
Presentation 692.24 / Y38 Bilateral transfer of working memory traces in prefrontal cortex
*S. L. BRINCAT1, J. A. DONOGHUE2, M. LUNDQVIST1, M. K. MAHNKE3, E. K. MILLER4;
2Brain and Cognitive Sci., 3PILM, 1MIT, Cambridge, MA; 4Picower Inst. Learning Memory, Massachusetts Inst. Technol., Cambridge, MA Display Abstract
Session 694 Cortical and Cortico-Hippocampal Circuits: Spatial Navigation IV
10:00 AM - 11:00 AM
Presentation 694.07 / Z21 Neural correlates of locomotion, cues, and context in the interactions between hippocampus and lateral septum
*H. S. WIRTSHAFTER1, M. A. WILSON2;
2Picower Inst. Learn/Memory, 1MIT, Cambridge, MA
Session 703 Optical Methods: Applications
8:00 AM - 12:00 PM
Presentation 703.07 / DP14/CC40 Label free characterization of attenuation lengths of cortical regions via three photon microscopy in awake mice
*M. YILDIRIM1, M. HU1, P. SO2, M. SUR3;
1Picower Inst. for Learning and Memory, 2Dept. of Biol. Engin., 3Dept. of Brain and Cognitive Sci., MIT, Cambridge, MA
Session 706 Analytical Computational Models
11:00 AM - 12:00 PM
Presentation 706.12 / DD23 Efficient robust spectral analysis of spike data
*A. H. SONG1, P. L. PURDON5, E. N. BROWN2,6,3,7,4, D. BA8;
1Electrical Engin. and Computer Sci., 2Brain and Cognitive Sci., 3Picower Inst. for Learning and Memory, 4Inst. for Med. Engin. and Sci., MIT, Cambridge, MA; 5Anesthesia, Critical Care, and Pain Mgmt., Massachusetts Gen. Hosp., Charlestown, MA; 6Anesthesia, Critical Care, and Pain Mgmt., 7Neurol., Massachusetts Gen. Hosp., Boston, MA; 8Sch. of Engin. and Applied Sci., Harvard Univ., Cambridge, MA
Session 723 Neural and Molecular Mechanisms of Memory
2:15 PM - 2:30 PM
Presentation 723.06 Mef2 mediates cognitive enhancement and resilience in mice and humans
*S. BARKER;
MIT, Cambridge, MA
Session 729 Neuron-Glia Interactions
4:00 PM - 5:00 PM
Presentation 729.08 / A8 Glial cell dysfunction as a result of 3D genome architecture changes in Trisomy-21 in iPSC and Ts65Dn mouse models
*E. R. LOCKSHIN1, G. KUFFNER2, H. MEHARENA3, L.-H. TSAI2;
1Picower Inst. For Learning and Memory, Cambridge, MA; 3Picower Inst. for Learning and Memory, 2MIT, Cambridge, MA
Session 733 Rett Syndrome: Molecular and Cellular Mechanisms
3:00 PM - 4:00 PM
Presentation 733.11 / A75 Early molecular and cellular deficits in 3D cerebral organoid models of Rett syndrome
*V. A. PHAM1, C. DELEPINE1, H. W. S. TSANG1, N. MORSHED2, F. WHITE2, M. SUR1;
1Brain and Cognitive Sci., Picower Inst. for Learning and Memory, Massachusetts Inst. of Technol., Cambridge, MA; 2Biol. Engin., David H. Koch Inst. for Integrative Cancer Research, Massachusetts Inst. of Technol., Cambridge, MA
Session 771 Biological Rhythms: Entrainment and Phase Shifts
2:00 PM - 3:00 PM
Presentation 771.06 / S11 Extended gamma sensory stimulation in cognitively normal individuals
*B. JACKSON1,2, D. CHAN1,3, H.-J. SUK2, S. BEACH1, D. STARK1, V. FERNANDEZ1, N. MILMAN1, C. STEARNS1, E. BOYDEN2, E. BROWN1, L.-H. TSAI1;
1Picower Inst. of Learning and Memory, Massachusetts Inst. of Technol., Cambridge, MA; 2McGovern Inst. for Brain Research, Massachusetts Inst. of Technol., Cambridge, MA; 3Dept. of Neurology, Massachusetts Gen. Hosp., Boston, MA
3:00 PM - 4:00 PM
Presentation 771.07 / S12 Bimodal stimulation in cognitively healthy individuals prompts widespread 40 Hz entrainment and global synchronization: A preliminary study of non-invasive stimulation for treating Alzheimer’s disease
*N. E. P. MILMAN1, D. CHAN1,3, H. J. SUK2,1, B. L. JACKSON2,1, S. BEACH1, D. STARK1, V. FERNANDEZ1, C. STEARNS1, E. N. BOYDEN2, E. S. BROWN1, L. H. TSAI1;
1Picower Inst. for Learning and Memory, 2McGovern Inst. for Brain Res., MIT, Cambridge, MA; 3Neurol., Massachusetts Gen. Hosp., Boston, MA