… showed that NMDA receptors trigger long ‐ term depression (LTD) as well as long ‐ term potentiation (LTP) in the cortex, that the properties of LTD and LTP are themselves 'metaplastic' and depend on the … of the visual cortex. His lab’s demonstration of LTD in the hippocampus was paradigm ‐ shifting, opening the …
… connections by a mechanism called long-term depression, or LTD. Subsequent studies in Bear’s Lab have led to potential therapies for disorders related to LTD. One is the common vision disorder amblyopia, in which … genetic loss of a protein called FMRP leads to too much LTD. His lab has discovered that intervening in the molecular …
… weak input , a plasticity called long-term depression (LTD) . LTD explain ed how monocular deprivation weakens an occluded … But Bear’s research on plasticity, including mechanisms of LTD, has also revealed that plasticity itself is plastic ( he …