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… supplements neurodegeneration Cellular and Molecular ApoE lipid metabolism … Julia Maeve Bonner. Lipid dysregulation The human gene for APOE, or apolipoprotein E, comes in three versions. While … and APOE3, the most common variant, is neutral. APOE is known to be involved in lipid metabolism, but its …

… via an investigation of why the APOE4 variation of the APOE gene constitutes the biggest genetic risk factor for … when pericyte cells have APOE4, they churn out too much APOE protein, which causes amyloid to clump together in blood …

… lipids in the brain neurodegeneration myelination ApoE lipid metabolism epigenetics …

… study finds organoids iPSCs stem cells neurodegeneration ApoE lipid metabolism … this APOE4 allele presents such a risk,” Tsai says. The APOE gene also comes in two other forms, known as APOE2, … and engineer them to express a specific version of the APOE gene. These cells can then be stimulated to …

… drugs could help stem cells iPSCs neurodegeneration ApoE cerebrovasculature blood … About 25 percent of people have the APOE4 variant of the APOE gene, which puts them at substantially greater risk for … variant, pericytes in their vessels churn out too much APOE protein, explained senior author Li-Huei Tsai , Picower …