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… focus on research including Alzheimer’s disease and Down syndrome neurodegeneration Tsai, who has grown the MIT … focus on research including Alzheimer’s disease and Down syndrome Picower Professor Li-Huei Tsai , who has led …

… autism and devising treatment strategies autism Fragile X Syndrome synapse formation synapse function prefrontal cortex … feet.” In 2007 his lab showed that genetically knocking down mGluR5 activity significantly improved many symptoms for … readout to guide how much medicine an individual needs. Down the hall from Bear’s lab in The Picower Institute is …

… project to make circuit connections. When those break down, the connections follow suit. synapse formation synapse … project to make circuit connections. When those break down, the connections follow suit. Perhaps the most obvious … but don’t eliminate, Perlecan can cause Schwartz-Jampel syndrome , in which patients experience neuromuscular …

… it benefit patients with Parkinson’s disease? What about Down syndrome? With an in-house, physician-led team, Tsai can … therapy to turn into a medicine, going all the way down the long, complicated road from lab bench to patient …

… multiphoton microscopy LTD amblyopia autism IGF1 Rett syndrome visual cortex visual system Vision isn’t necessary … experimental stimulation. Visual information transmitted down the optic nerve from the retinas is relayed by the LGN … that while lid closure caused MD, completely shutting down the retina with a dose of the chemical TTX did not. With …

… testbeds and applying them to study conditions such as Down syndrome, Alzheimer’s disease, Rett syndrome, and Zika virus … amyloid protein in green. As part of the work in the Alana Down Syndrome Center, Tsai’s lab is also using iPSC-based …

… organoid, or “minibrain,” models of diseases such as Rett Syndrome or Zika virus infection. Minyoung E. Kim presented a … allowed the Chung and Susumu Tonegawa labs to track down the ensemble of neurons that form a contextual memory, … choice. Scott Brincat, meanwhile, showed how he’s tracked down the means by which the brain’s working memory system …

… , is likely consequential in people with 16p11.2 deletion syndrome . Accounting for up to 1 percent of autism cases, … protein-encoding genes leads to clinical symptoms of the syndrome such as autism-like behaviors, developmental delay … the opposite. Sure enough, when the researchers knocked down STAT1 as well as MVP, they were able to bring back a …

… insights, innovations Bipolar Disorder amblyopia Rett syndrome Cdk5 LTD MECP2 CPG2 CPG15 Developing minds are … that when a protein called p35 that regulates Cdk5 breaks down into p25, the ensuing overactivity of Cdk5 leads to … in diverse ways. In one program, her lab is investigating Down syndrome by using induced stem cells from patients to …

… science is to take a break from their day-to-day, heads-down focus for a change of scenery that enables new ways of … neuroscience methodology that could be adapted by our lab down the road.” PIcower Institute members engage in a "speed … she enjoyed hearing about how Ojha studies them in Rett syndrome. “Over the years I feel that the retreats have been …