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… How microglia contribute to Alzheimer’s disease August 4, 2022 … A new study from MIT shows how a type of cells called microglia contribute to this slowdown of neuron activity. The study found that microglia that express the APOE4 gene, one of the strongest …

… have implicated molecular cross-talk with the brain’s microglia immune cells. Notably, when the researchers cultured APOE4 miBrains without microglia, their production of phosphorylated tau was … APOE4 miBrains with culture media from astrocytes and microglia combined, phosphorylated tau increased, whereas …

… on preserving epigenomic stability. neurodegeneration microglia astrocytes epigenetics chromatin Single Cell … cell types that were especially vulnerable including microglia that play immune and other roles, oligodendrocytes … genetic risk factor for Alzheimer’s. In APOE4 brains, microglia initially responded to the emerging disease …

… 40Hz gamma Alzheimer's dementia neurodegeneration microglia astrocytes … responses in many brain cell types including neurons, microglia, astrocytes, oligodendrocytes and the brain’s blood … responses. Meanwhile the nature of how some cells, such as microglia, respond to gamma stimulation and how that affects …

… disease neuroimmunology Neuroimmune interactions microglia neurodegeneration dementia … delivered small interfering RNA (siRNA) to the brain’s microglia immune cells to suppress expression of a protein … new study also demonstrates a new way to deliver RNA to microglia, which have been difficult to target so far.   …