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… and neurodevelopmental disorders – FMRP stands for “Fragile X Mental Retardation protein” because it is central to the genetic, autism-like condition Fragile X syndrome; and prior studies have linked neurogranin to …

… molecular mechanism underlying neural hyperexcitability in fragile X syndrome, a profound autism spectrum disorder. In her talk, …

… downstream of mGluR5 is exaggerated in the mouse model of fragile X (FX). Human FX is caused by the silencing of the FMR1 gene, … for Outstanding Contributions to Understanding Fragile X Syndrome, National Fragile X Foundation, 2006 Brown …

… organoid, or “minibrain,” models of diseases such as Rett Syndrome or Zika virus infection. Minyoung E. Kim presented a … of the Bear lab examined whether a promising treatment for Fragile X syndrome may have been hindered by tolerance at the point …

… Brain and Cognitive Sci., MIT, Cambridge, MA Session P055 Fragile X: Cellular Mechanisms 2:30 PM - 3:30 PM Presentation P055.06 … novel therapeutic targets for the treatment of fragile X syndrome *M. J. HEINRICH , D. C. STOPPEL, F.-J. WENG, P. K. …

… form of LTD have also led to key discoveries about Fragile X syndrome, a genetic cause of autism and intellectual …

… have revealed a promising treatment for Rett syndrome: In 2009 the lab showed how a protein that is … Auerbach described how his team has used rats modeling Fragile X syndrome to understand, at multiple levels of brain …

… reward neurons form and store fear extinction memory *X. ZHANG 1 , J. KIM 2 , S. TONEGAWA 3 ; 1 Dept. of Brain and … of Neural Progenitor Cells as a Consequence of Down Syndrome *H. MEHARENA 1 , L.-H. TSAI 2 ; 1 MIT, Cambridge, … overcoming pharmacological tolerance in the treatment of fragile-X syndrome *P. K. MCCAMPHILL 1 , R. K. SENTER 1 , H. …