In Down syndrome cells, genome-wide disruptions mimic a senescence-like state
Extra chromosome alters chromosomal conformation and DNA accessibility across the whole genome in neural progenitor cells, disrupting gene transcription and cell functions much like in cellular aging.
Research finds potential mechanism linking autism, intestinal inflammation
Moms infected during pregnancy who produce elevated levels of the cytokine IL-17a may have microbiome alterations that prime offspring for aberrant immune responses later in life, mouse study suggests
Feast or forage: Study finds circuit that helps a brain decide
By integrating multiple sensory inputs, a loop of mutual inhibition among a small set of neurons allows worms to switch between long-lasting behavioral states
Scholars from around the world gathered online to share new research on how intricately structured neural processes enable plasticity of circuit connections and help integrate incoming information to enable brain function
NIH award funds innovative investigation of neurodegenerative motor diseases
Large-scale, integrated application of advanced computational, biological techniques aims to discover mechanisms underlying ALS and frontotemporal lobar degeneration with motor neuron disease
Study shows fragile X treatment can incur resistance, suggests ways around it
While the brain acquires resistance to continuous treatment with mGluR5 inhibitor drugs, lasting effects may still arise if dosing occurs intermittently and during a developmental critical period