… brain cells such as oligodendrocytes, astrocytes, and microglia. The researchers found that each of these cell … neurodegeneration , epigenetics , glia , astrocytes , microglia , dementia , aging Print Share Related Articles …
… activity, for instance increasing the activity of microglia, specialized brain cells that clear away harmful … One or More Print eNewsletter Events Submit Read more microglia , oscillations , cognitive control , working memory …
… director of inflammatory gene expression in the brain’s microglia immune cells. A11 suppresses this problematic PU.1 … study demonstrates that A11 reduces inflammation in human microglia-like cells as well as in multiple mouse models of … a 2015 study that implicated PU.1 as a regulator of errant microglia inflammation in a mouse model of Alzheimer’s …
… delivered small interfering RNA (siRNA) to the brain’s microglia immune cells to suppress expression of a protein … new study also demonstrates a new way to deliver RNA to microglia, which have been difficult to target so far. … that LNPs might work as a way to bring siRNA into microglia because the cells, which clear waste in the brain, …
… genes, and found that many of them occur most often in microglia, the immune cells responsible for clearing debris … which contributes to loss of cell identity. The role of microglia In a third Cell paper, led by MIT graduate student … Matheus Victor, the researchers focused primarily on microglia, which make up 5 to 10 percent of the cells in the …
… contributes to disease progression and chronicity. Microglia play a pivotal role in this immune response and are … the release of inflammatory mediators, but also distracts microglia cells from their physiological functions and tasks, … ASC specks contribute to spreading of pathology and impair microglia clearance mechanisms, and together contribute to …