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Study shows how specific gene variants may raise bipolar disorder risk

January 09, 2019
… diagnosis Bipolar Disorder synapse function CPG2 candidate plasticity genes plasticity genes plasticity … bipolar disorder was CPG2 significantly lower. Other key synaptic proteins were not uniquely lower in bipolar … BD disrupt the levels and function of a protein crucial to synaptic activity and therefore the health of neural …

How brain cells pick which connections to keep

August 06, 2019
… synapse formation synapse assembly synapse disassembly synaptic plasticity CPG15 PSD multiphoton microscopy … excitatory synapses are formed, and the recruitment of the synaptic scaffold, PSD95, that signals that a synapse is …

Treating Amblyopia

… another problem that deprives an eye of clear sight, the synaptic connections from the affected eye are weakened in … 8. Through decades of study of the fundamental workings of synaptic plasticity, Mark Bear has helped to discover that the …

How synapses change

… the brain flexible and adaptable (a property called “plasticity”). If it weren’t, we couldn’t learn or remember … are built to change and how both the “pre-” and “post-” synaptic sides of a synapse interact to set plasticity in motion. In 2005, for example, Littleton and lab …

Colloquium on the Brain and Cognition with Daniel Colón-Ramos, PhD, "Powering the Nervous System: Energy Distribution in the Connectome"

… in a functional connectome, much like the structure of synaptic positions in an anatomical connectome, represents a … shapes information flow and circuit function, including plasticity. To address this hypothesis it is necessary to … enzymes are organized within polarized neurons to support synaptic function, 2) How glycolytic energy states within …

What separates the strong from the weak among connections in the brain

July 10, 2018
… how they get that way. By pinpointing the properties of synaptic strength and how they develop, the study could help … synapses might be made weaker or stronger. Deficiencies in synaptic development and change, or plasticity, have a role in many brain diseases such as autism …
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