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… of ApoE, and the increasingly recognized role of lipid metabolism in Alzheimer’s disease.  "Unearthing these … DEGs associated with AD are linked to lipid/cholesterol metabolism, to AD genetic risk factors (including ApoE) and …

… which showed that APOE4-induced dysfunction of lipid metabolism in neurons by cellular accumulation of unsaturated … pathway in neuronal cells, thus stabilizing the lipid metabolism and concomitantly restoring normal cell function …

… mechanism: ferroptosis. This phenomenon, in which errant metabolism of iron leads to a lethal buildup of reactive …

… laboratory in the Division of Endocrinology, Diabetes, and Metabolism at Beth Israel Deaconess Medical Center (BIDMC) in …