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… Tsai’s lab has been studying whether it can help with Down syndrome as well. The open questions may help define the next …

… science is to take a break from their day-to-day, heads-down focus for a change of scenery that enables new ways of … neuroscience methodology that could be adapted by our lab down the road.” PIcower Institute members engage in a "speed … she enjoyed hearing about how Ojha studies them in Rett syndrome. “Over the years I feel that the retreats have been …

… , is likely consequential in people with 16p11.2 deletion syndrome . Accounting for up to 1 percent of autism cases, … protein-encoding genes leads to clinical symptoms of the syndrome such as autism-like behaviors, developmental delay … the opposite. Sure enough, when the researchers knocked down STAT1 as well as MVP, they were able to bring back a …

… insights, innovations Bipolar Disorder amblyopia Rett syndrome Cdk5 LTD MECP2 CPG2 CPG15 Developing minds are … that when a protein called p35 that regulates Cdk5 breaks down into p25, the ensuing overactivity of Cdk5 leads to … in diverse ways. In one program, her lab is investigating Down syndrome by using induced stem cells from patients to …

… during a developmental critical period mGluR5 Fragile X Syndrome autism spectrum disorders … that a severe developmental brain disorder —fragile X syndrome—might be treated with drugs that inhibit a … gave up initial progress after chronic dosing in tamping down protein synthesis in a brain region called the …

… such as the fly version of insulin, from the neuron body down its long axon to synapses at the other end, and how … David Stoppel showed how he uses mice to study fragile X syndrome, a form of autism. Stoppel demonstrated how he … mice. That might help explain why people with Fragile X syndrome can experience hypersensitivity to sensory …

… with schizophrenia, bipolar disorder, depression, Rett syndrome, Alzheimer's disease, Down syndrome, and healthy person’s skin fibroblasts as controls. …

… for conditions such as Alzheimer's disease and Rett Syndrome. Afif Aqrabawi Susumu Tonegawa Engrams are ensembles … 3D cerebral organoids derived from patients with Rett syndrome, Delepine is exploring the molecular mechanisms … plasticity in the prefrontal cortex of rodent models of Down Syndrome.  In the Bear lab, she investigated how …