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… Memory Public Event The Cellular and Molecular Basis of Synaptic Plasticity My lab is interested in elucidating the … a long lasting (many weeks) enhancement in the strength of synaptic transmission, is generally accepted to be a key cellular …

… recently, we have started to examine how manipulating NMDA synaptic function pharmacologically distorts neural dynamics … In particular, we are exploring a hypothesis that synaptic insults that increase risk of schizophrenia operate … two negative consequences: (1) it disrupts the effective transmission of information in prefrontal networks, and (2) …

… destroying synapses that are no longer necessary. Such “synaptic pruning” is an essential function for helping brain … in a fatty insulation called myelin that enables faster transmission of electrical signals. This vital process for …

… Genomics and Proteomics Neural Plasticity Mood Disorders synaptic plasticity synapse assembly synapse disassembly … genes important for neuronal survival, connectivity, and synaptic transmission, suggesting that activity-regulated genes are …

… 46-4243A 617-452-2662 kjo@mit.edu Action potentials and synaptic transmission occur over the time scale of milliseconds, yet … animal, and a complete connectome has defined all of the synaptic contacts between these neurons. In addition, we can …