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… of science, technology, engineering, and mathematics (STEM) education and to community service as demonstrated by …

… decided to explore the role of sirtuins in endothelial cells, which line the inside of blood vessels. To do that, … which encodes the major mammalian sirtuin, in endothelial cells of mice. They found that at 6 months of age, these mice … Vittorio Sartorelli, chief of the Laboratory of Muscle Stem Cells and Gene Regulation at the National Institute of …

… of Alzheimer’s disease, which affects many types of cells in the brain including its blood vessels, has proven … and validated such an in vitro BBB from patient-derived stem cells. Moreover, he made versions with the Alzheimer’s risk …

… MIT shows that this gene has widespread effects on brain cells’ ability to metabolize lipids and respond to stress. In studies of human brain cells and yeast cells, the researchers found that the APOE4 … the researchers created human induced pluripotent stem cells that carry either the APOE3 or APOE4 gene in an …

… the harmful inflammatory response of the brain’s immune cells, reducing disease pathology, preserving neurons and … the harmful inflammatory response of the brain’s immune cells, reducing disease pathology, preserving neurons and … of human microglia-like cells cultured from patient stem cells. When they exposed the microglia-like cells to …

… than the more common and risk-neutral APOE3 version, cells called oligodendrocytes mismanage cholesterol, failing … available , encompasses more than 160,000 individual cells of 11 different types from the prefrontal cortex of 32 … why, the team used patient-derived induced pluripotent stem cells to create lab cell cultures of oligodendrocytes …

… iPS Core Facility The advent of human induced pluripotent stem cells (iPSCs) has heralded a new generation of clinical and … into human disorders. Patient-derived skin fibroblast cells are reprogrammed into iPS cells, which allow …

… immune molecule called IL-17a, which is produced by immune cells during a fever, can temporarily reduce some of the … sciences, working with David Anderson. Anderson, a stem cell biologist, was switching his lab’s focus to …

… of brain tissue grown from human induced pluripotent stem cells.   “We have developed a 3D model of human myelination … aging and Alzheimer’s disease influence myelinating cells and neuronal health.” Using the cultures, he’ll be able …