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Roots of APOE4-related Alzheimer’s pathology

… Tsai has pioneered the use of human induced pluripotent stem cell (iPSC) models to understand how APOE4 adversely … “isogenic” lines of neuron, astrocyte and microglia brain cells, showed that ApoE4 changes lipid metabolism in … and the blood-brain barrier, her lab found that pericyte cells carrying ApoE4 increased ApoE protein expression, …

Picower Fellows alumni

… vascularize cerebral organoids grown from patient-derived stem cells. They have the potential to mimic disease on a … synapses and in vivo imaging of transplanted human stem cellderived neurons in the mouse visual cortex. Sayak …

Deep in vivo molecular imaging

… tissues to detect the molecular activity of individual cells by using sound. In the journal Light: Science and … a 3D-mini brain-like tissue generated from human stem cells, and a 0.7-milimeter-thick slice of mouse brain tissue. …

SCOUT

… to culture cerebral organoids, or “minibrains,” using stem cells derived from people has given scientists experimentally … recognize and track architectural patterns formed by the cells as the organoids develop or are affected in models of …

Starting off the year with new skills, new connections

January 09, 2024
… that primarily serve groups underrepresented in STEM fields took part in the QMW, said organizer Mandana … shared experience Undergraduates and faculty in various STEM disciplines often come to QMW to gain an understanding …

Tiny brains grown in 3D-printed bioreactor

April 07, 2021
… develop, and be studied in real time organoids Cellular stem cells iPSCs https://aip.scitation.org/doi/10.1063/5.0041027 … by exposing it to UV light, then sterilized before live cells were placed in the wells. After sealing the top of the …
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