Thursday, Jan 06
… In Down syndrome cells, genome-wide disruptions mimic a senescence-like state … correct them in cell cultures. The study published in Cell Stem Cell therefore establishes senescence as a potentially … only by whether they had a third copy of chromosome 21. Stem cells derived from volunteers were cultured to turn into …
… iPS Core Facility The advent of human induced pluripotent stem cells (iPSCs) has heralded a new generation of clinical and … in human cells. The advent of human induced pluripotent stem cells (iPSCs) has heralded a new generation of clinical …
Thursday, May 31
… the more common form of the gene, APOE3. Studying brain cells derived from a type of induced human stem cells, the researchers found that APOE4 promotes the … to answer that question using human induced pluripotent stem cells — stem cells derived from skin or other cell …
Monday, Dec 16
… Human Models of Disease December 16, 2019 News Feature Stem cell, genetic technologies enable sophisticated studies of human brain cells and brain "organoids" For decades, neuroscientists … and to “reprogram” it to become an “induced pluripotent stem cell” (iPSC) that can then be biochemically guided to …
Thursday, Jun 23
… research labs at MIT to get information and inspiration stem cells autism drosophila neurodegeneration Just before school … careers. “It helps them focus on the different fields of STEM they could choose,” said Everett Academy Lead Teacher …
Wednesday, Mar 03
… MIT shows that this gene has widespread effects on brain cells’ ability to metabolize lipids and respond to stress. In studies of human brain cells and yeast cells, the researchers found that the APOE4 … the researchers created human induced pluripotent stem cells that carry either the APOE3 or APOE4 gene in an …
Tuesday, Oct 05
… to pinpoint what may be going wrong in specific brain cells and to help identify new treatment approaches. The … nervous system tissue, to precision genetic engineering of stem cells and animal models. This unique blend of … in a high throughput manner. Using induced pluripotent stem cells derived from patients, they will culture many …
Wednesday, Jul 31
… neurodevelopmental disorder Rett syndrome CRISPR/Cas9 stem cells neurodevelopmental disorders autism spectrum disorders … KCC2 gene activity. Using CRISPR/Cas9 genome editing and stem cell technologies, they engineered human neurons to …
… and cultured cell lines, including induced pluripotent stem cells (iPSCs) and iPSC-derived cell lines; tissue culture (stem cells, neuronal progenitors, neurons), stem cell ... …
Thursday, Feb 21
… single-cell profiling, “big data” integration, induced stem-cell reprogramming, mini-brain organoids, tissue … genes and the cell types where they act, and engineer cells, tissues and mouse models to test their hypotheses and … then test these genes/pathways in the induced pluripotent stem cells (iPSC) system coupled with CRISPR-Cas9 to …
