… iPS Core Facility The advent of human induced pluripotent stem cells (iPSCs) has heralded a new generation of clinical and … in human cells. The advent of human induced pluripotent stem cells (iPSCs) has heralded a new generation of clinical …
Thursday, May 31
… the more common form of the gene, APOE3. Studying brain cells derived from a type of induced human stem cells, the researchers found that APOE4 promotes the … to answer that question using human induced pluripotent stem cells — stem cells derived from skin or other cell …
Monday, Dec 16
… Human Models of Disease December 16, 2019 News Feature Stem cell, genetic technologies enable sophisticated studies of human brain cells and brain "organoids" For decades, neuroscientists … and to “reprogram” it to become an “induced pluripotent stem cell” (iPSC) that can then be biochemically guided to …
Wednesday, Jul 31
… neurodevelopmental disorder Rett syndrome CRISPR/Cas9 stem cells neurodevelopmental disorders autism spectrum disorders … KCC2 gene activity. Using CRISPR/Cas9 genome editing and stem cell technologies, they engineered human neurons to …
Thursday, Feb 21
… single-cell profiling, “big data” integration, induced stem-cell reprogramming, mini-brain organoids, tissue … genes and the cell types where they act, and engineer cells, tissues and mouse models to test their hypotheses and … then test these genes/pathways in the induced pluripotent stem cells (iPSC) system coupled with CRISPR-Cas9 to …
… she made the breakthrough discovery that radial glial cells are neural stem cells. This inspired her to attempt turning also adult … injury when she was appointed Director of the Institute of Stem Cell Research at the Helmholtz Center Munich in 2004 and …
Wednesday, May 01
… of the genes that are expressed in individual brain cells of patients with Alzheimer’s disease. The results … that are affected in neurons and other types of brain cells. This analysis could offer many potential new drug … are now using mouse and human induced pluripotent stem cell models to further study some of the key cellular …
Monday, Jun 08
… pinpoint mechanism and demonstrate drugs could help stem cells iPSCs neurodegeneration … Tsai and co-authors coaxed human induced pluripotent stem cells to become the three types of cells that make up …
Thursday, Mar 22
… decided to explore the role of sirtuins in endothelial cells, which line the inside of blood vessels. To do that, … which encodes the major mammalian sirtuin, in endothelial cells of mice. They found that at 6 months of age, these mice … Vittorio Sartorelli, chief of the Laboratory of Muscle Stem Cells and Gene Regulation at the National Institute of …
… beta HDAC2 epigenetics CRISPR/Cas9 iPSCs multiphoton stem cells neurodegeneration 46-4235 617-324-1658 tsaiasst@mit.edu … calpain-resistant p35 alleles in human induced pluripotent stem cells (iPSCs) derived from AD patients (see below) to …
