… iPS Core Facility The advent of human induced pluripotent stem cells (iPSCs) has heralded a new generation of clinical and … in human cells. The advent of human induced pluripotent stem cells (iPSCs) has heralded a new generation of clinical …
Thursday, May 31
… the more common form of the gene, APOE3. Studying brain cells derived from a type of induced human stem cells, the researchers found that APOE4 promotes the … to answer that question using human induced pluripotent stem cells — stem cells derived from skin or other cell …
Monday, Dec 16
… Human Models of Disease December 16, 2019 News Feature Stem cell, genetic technologies enable sophisticated studies of human brain cells and brain "organoids" For decades, neuroscientists … and to “reprogram” it to become an “induced pluripotent stem cell” (iPSC) that can then be biochemically guided to …
Wednesday, Mar 03
… MIT shows that this gene has widespread effects on brain cells’ ability to metabolize lipids and respond to stress. In studies of human brain cells and yeast cells, the researchers found that the APOE4 … the researchers created human induced pluripotent stem cells that carry either the APOE3 or APOE4 gene in an …
Wednesday, Jul 31
… neurodevelopmental disorder Rett syndrome CRISPR/Cas9 stem cells neurodevelopmental disorders autism spectrum disorders … KCC2 gene activity. Using CRISPR/Cas9 genome editing and stem cell technologies, they engineered human neurons to …
Thursday, Feb 21
… single-cell profiling, “big data” integration, induced stem-cell reprogramming, mini-brain organoids, tissue … genes and the cell types where they act, and engineer cells, tissues and mouse models to test their hypotheses and … then test these genes/pathways in the induced pluripotent stem cells (iPSC) system coupled with CRISPR-Cas9 to …
Monday, May 10
… brain development. To make organoids, scientists take skin cells from a donor, induce them to become stem cells and then culture those in a bioreactor, guiding … factors and other chemicals. Over the course of weeks, the stem cells become progenitor cells that multiply and then go …
… she made the breakthrough discovery that radial glial cells are neural stem cells. This inspired her to attempt turning also adult … injury when she was appointed Director of the Institute of Stem Cell Research at the Helmholtz Center Munich in 2004 and …
Tuesday, Oct 06
… expression of another Alzheimer’s-associated gene in those cells could help alleviate the problem. About 25 percent of … such as these cells derived from induced pluripotent stem cells, are critical for brain function. The research … a series of lab experiments in cultures of stem cell-derived human astrocytes and genetically engineered …
Wednesday, May 01
… of the genes that are expressed in individual brain cells of patients with Alzheimer’s disease. The results … that are affected in neurons and other types of brain cells. This analysis could offer many potential new drug … are now using mouse and human induced pluripotent stem cell models to further study some of the key cellular …
