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… broadly CPG15 multiphoton microscopy LTD amblyopia autism IGF1 Rett syndrome visual cortex visual system Vision isn’t … mice raised in the dark or with MD. A protein called IGF1 stood out. Artificially adding it prevented ODP. As they studied IGF1 more they realized that it promoted synaptic maturation …

… from experience plasticity candidate plasticity genes IGF1 autism A Picower Institute primer on ‘plasticity,’ the … to synaptic maturation comes via a protein called IGF1 that is reduced among people with Rett. That insight … them to show that treating Rett-model mice with extra IGF1 peptide or IGF1 corrected many defects of MECP2 …

… was published by MIT in 2009. Rett syndrome plasticity IGF1 neurodevelopmental disorders MECP2 … paper in PNAS showing that doses of recombinant human IGF1 were effective in mice. And I was also the co-author in …

… Disease candidate plasticity genes Bipolar Disorder IGF1 mGluR5 CPG2 DNA’s resemblance to a twisted ladder … 2006, Sur’s lab discovered evidence that a protein called IGF1 is a crucial component in how synapses in the visual … in newborn mice develop in response to visual activity . IGF1 is regulated by MECP2 and is indeed notably reduced in …