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… improve diagnosis Bipolar Disorder synapse function CPG2 candidate plasticity genes plasticity genes plasticity … for Learning and Memory at MIT finds that the protein CPG2 is significantly less abundant in the brains of people … one and only.” The researchers are not suggesting that the CPG2-related variations in SYNE1 are “the cause” of bipolar …

… and synaptic function of two previously unknown CPGs: CPG2 and CPG15. In a study published earlier this year, her lab showed that the protein CPG2 is significantly less abundant in the brains of people … how specific mutations in the SYNE1 gene that encodes CPG2 undermine the protein’s expression and its function in …

… candidate plasticity genes Bipolar Disorder IGF1 mGluR5 CPG2 DNA’s resemblance to a twisted ladder provides an apt … of these variants which affect expression or function of CPG2, a key protein encoded by SYNE1, are sufficient to … you will develop the disease .”   Nedivi ’s lab discovered CPG2 while screening neurons for proteins whose expression …

… During years of fundamental studies, Nedivi discovered CPG2, a protein expressed in response to neural activity that … receptors at excitatory synapses. The gene encoding CPG2 was recently identified as a risk gene for b ipolar d … people with bipolar disorder indeed had reduced levels of CPG2 because of variations in the SYNE1 gene . When they …