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… drugs could help stem cells iPSCs neurodegeneration ApoE cerebrovasculature blood … About 25 percent of people have the APOE4 variant of the APOE gene, which puts them at substantially greater risk for … variant, pericytes in their vessels churn out too much APOE protein, explained senior author Li-Huei Tsai , Picower …

… However, little is known about why this version of the APOE gene, which is normally involved in metabolism and … (left) than the APOE3 tissue (right). Amyloid accumulation APOE, also called apolipoprotein E, comes in three variants, known as 2, 3, and 4. APOE binds to cholesterol and lipids in cells’ environments, …

… versions of the leading risk gene for Alzheimer’s disease, APOE. People with the APOE4 variant are at much higher risk … of the brain through the blood stream, so he can see how APOE variants affect that. Researchers are also looking at …

… lab sought to understand how APOE4 affects microglia. The APOE gene, of which APOE4 is a harmful variation, determines …

… biggest genetic risk factor, the APOE4 variant of the APOE gene.   Li-Huei Tsai As with autism spectrum disorders, …