Systems Neuroscience

Picower Institute scientists seek to understand the complex circuits and processes that the brain constructs and employs so that we can perceive, learn, think, plan, and feel. To learn more about these or other areas of inquiry, select them under Research Topics and you'll find relevant Picower people, discoveries and events.

Li-Huei Tsai

Picower Professor of Neuroscience
The Tsai lab is interested in elucidating the pathogenic mechanisms underlying neurological disorders that impact learning and memory by taking a multidisciplinary approach to investigate the molecular, cellular, and circuit basis of neurodegenerative disorders.

Brady Weissbourd

Doherty Assistant Professor of Biology
Brady Weissbourd uses jellyfish to study nervous system evolution, development, regeneration, and function.

Matthew Wilson

Sherman Fairchild Professor in Neurobiology
Research in the Wilson laboratory focuses on the study of information representation across large populations of neurons in the mammalian nervous system, as well as on the mechanisms that underlie formation and maintenance of distributed memories, and the role of sleep in memory.

Study finds circular RNA helps drive brain development

October 16, 2025
Research Findngs
MIT neuroscientists show in a new study that loops of RNA can strongly influence how neurons build circuit connections, or synapses, during the development of the visual system in young mice.

Neural activity helps circuit connections mature into optimal signal transmitters

October 14, 2025
Research Findngs
By carefully tracking the formation and maturation of synaptic active zones in fruit flies, MIT scientists have discovered how neural activity helps circuit connections become tuned to the right size and degree of signal transmission

How the brain splits up vision without you even noticing

September 22, 2025
Research Findngs
As an object moves across your field of view, the brain seamlessly hands off visual processing from one hemisphere to the other like cell phone towers or relay racers do, a new MIT study shows.

Study finds key role for non-neural brain cells in processing vision

July 22, 2025
Research Findings
MIT researchers employed a novel application of tools and analysis to show that astrocytes ensure neural information processing by maintaining ambient levels of the neurotransmitter chemical GABA.

Connect or reject: Extensive rewiring builds binocular vision in the brain

July 1, 2025
Research Findings
A first-of-its-kind study in mice reveals that neurons add and shed synapses at a frenzied pace during development to integrate visual signals from the two eyes.

Autism advances

June 16, 2025
Research Feature
Rooted in fundamental curiosity about how the brain works, Picower scientists continue to break new ground in understanding autism and devising treatment strategies

The how and why of the brain’s division across hemispheres

May 12, 2025
Research Findings
Why does the brain split visual spatial perception between its hemispheres? A new review examines the advantages and trade-offs, and how the brain ultimately makes vision feel seamless.

Dopamine signals when a fear can be forgotten

April 28, 2025
Research Findings
Study shows how a dopamine circuit between two brain regions enables mice to extinguish fear after a peril has passed.

With Searle Scholar award, Fan will study serotonin role in memory

April 22, 2025
Picower People
Assistant Professor Linlin Fan will apply her lab’s precise “all-optical” techniques to study how serotonin might influence plasticity in memory, and whether psychedelics affect that.