Molecular and Cellular

Picower Institute scientists probe the role of genes, proteins and molecules in the physiology and action of neurons and glia, including how synaptic connections change. To learn more about these or other areas of inquiry, select them under Research Topics and you'll find relevant Picower people, discoveries and events.

Anesthesia doesn't simply turn off the brain, it changes its rhythms

April 27, 2021
Research Findings
Simultaneous measurement of neural rhythms and spikes across five brain areas in animals reveals how propofol induces unconsciousness

Study of synapse strength focuses on ‘active zones’

March 16, 2021
New Research
With new NIH grant, team will learn how neurons build key sites that release neurotransmitters a lot, or a little, to drive nervous system communication

Basic cell health systems wear down in Huntington’s disease, novel analysis shows

February 23, 2021
Research Findings
A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis

As you look around, mental images bounce between right and left brain

February 8, 2021
Research Findings
New study explains how the brain helps us remember what we’ve seen, even as it shifts around in our visual system

Scientists seek insight into Parkinson’s, addiction by tracking gene expression in the brain

January 4, 2021
New Research
Two MIT Brain and Cognitive Sciences faculty members earn funding from the G. Harold and Leila Y. Mathers Foundation

Playing chess, not checkers: Neurons dynamically control their myelin patterns

December 18, 2020
Research Findings
Researchers identify a new level of complexity in how the brain responds to stimuli

Genes & Disease

December 14, 2020
Research Feature
Picower scientists are making the dauntingly long but highly motivating climb between associating a gene with disease and developing potential treatments.

Down syndrome symposium highlights clinical, fundamental progress

November 20, 2020
Recent Events
Speakers describe studies to address Alzheimer’s disease, sleep apnea and to advance fundamental discoveries in cell and chromosome biology

Brown wins SfN’s Swartz Prize for Theoretical and Computational Neuroscience

October 26, 2020
Picower People
Award cites major contributions to statistical analysis of brain activity and advancing the neuroscience of anesthesia

Math shows how brain stays stable amid internal noise and a widely varying world

August 10, 2020
Research Findings
Theoretical framework shows that many properties of neural connections help biological circuits produce consistent computations

Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA

July 17, 2020
Research Findings
Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons

Seemingly similar, two neurons show distinct styles as they interact with the same muscle partner

July 7, 2020
Research Findings
Diversity in how cells talk to the muscle they innervate reveal distinct propensities for change, or “plasticity”