Disorders

Picower Institute scientists investigate the pathophysiological mechanisms underlying complex disorders of the brain that affect emotion and cognition. To learn more about research in these or other areas, select them under "Research Topics" and you'll find relevant Picower people, discoveries and events.

Scientists find a new way to reverse symptoms of Fragile X

May 20, 2020
Research Findings
Drug compound, tested in mice, could be effective in treating the leading heritable cause of intellectual disability and autism

Study finds that aging neurons accumulate DNA damage

May 18, 2020
Research Findings
Reactivating an enzyme that promotes DNA repair can help to reverse age-related cognitive decline in mice.

How could Covid-19 and the body’s immune response affect the brain?

April 21, 2020
Research Feature
Picower Institute researchers are embarking on experiments to learn the mechanisms by which coronavirus might affect mental health

‘Researching from Home’: Picower science stays strong even at a distance

April 1, 2020
News Feature
Institute researchers are advancing their work in many ways despite time away from the lab required to corral Covid-19

Look and Learn: Studying the visual system

March 13, 2020
Research Feature
Research on how the brain processes sight has told neuroscientists much about how the brain works more broadly

Genetic screen offers new drug targets for Huntington’s disease

January 30, 2020
Research findings
Neuroscientists identify genes that modulate the disease’s toxic effects

With these neurons, extinguishing fear is its own reward

January 15, 2020
Research findings
The same neurons responsible for encoding reward also form new memories to suppress fearful ones

Study may explain how infections reduce autism symptoms

December 18, 2019
Research Findings
An immune molecule sometimes produced during infection can influence the social behavior of mice.

Human Models of Disease

December 16, 2019
News Feature
Stem cell, genetic technologies enable sophisticated studies of human brain cells and brain "organoids"

Scientists eager to explain brain rhythm boost’s broad impact in Alzheimer’s models

December 9, 2019
Research findings
Paper lays out new areas of investigation

Tsai elected fellow of National Academy of Inventors

December 3, 2019
Picower People
Honor notes innovations in research addressing Alzheimer’s disease

Down syndrome symposium highlights potential progress at many scales

November 14, 2019
Events
The inaugural symposium of the Alana Down Syndrome Center