Cognition and Motivation

Picower Institute scientists study behaviors and cognitive processes including learning, memory, emotion, reasoning and consciousness. To learn more about these or other areas of inquiry, select them under Research Topics and you'll find relevant Picower people, discoveries and events.

Neurons are fickle. Electric fields are more reliable for information.

March 14, 2022
Research Findings
A new study suggests that electric fields may represent information held in working memory, allowing the brain to overcome “representational drift,” or the inconsistent participation of individual neurons

Research advances technology of AI assistance for anesthesiologists

February 2, 2022
Research Findings
A new deep learning algorithm trained to optimize doses of propofol to maintain unconsciousness during general anesthesia could augment patient monitoring

Feast or forage: Study finds circuit that helps a brain decide

November 22, 2021
Research Findings
By integrating multiple sensory inputs, a loop of mutual inhibition among a small set of neurons allows worms to switch between long-lasting behavioral states

Study links gene to cognitive resilience in the elderly

November 3, 2021
Research Findings
The findings may help explain why some people who lead enriching lives are less prone to Alzheimer’s and age-related dementia

'What Were you Thinking?'

September 20, 2021
Research Feature
How brain circuits integrate many sources of context to flexibly guide behavior

Statistical model defines ketamine anesthesia’s effects on the brain

September 3, 2021
Research Findings
Neuroscientists at MIT and Massachusetts General Hospital have developed a statistical framework that rigorously describes the brain state changes that patients experience under ketamine-induced anesthesia.

Brain’s ‘memory center’ needed to recognize image sequences but not single sights

July 26, 2021
Research Findings
The visual cortex stores and remembers individual images, but when they are grouped into a sequence, mice can’t recognize that without guidance from the hippocampus

Grant to help scientists test whether brain region is a key locus of learning

July 23, 2021
New Research
Long thought of as a generic alarm system, the locus coeruleus may actually be a sophisticated regulator of learning and behavior, an MIT team posits

Memory making involves extensive DNA breaking

July 6, 2021
Research Findings
To quickly express genes needed for learning and memory, brain cells snap both strands of DNA in many more places and cell types than previously realized, a new study shows

As novel sights become familiar, different brain rhythms, neurons take over

June 8, 2021
Research Findings
As ‘visual recognition memory’ emerges in visual cortex, one circuit of inhibitory neurons supplants another and slower neural oscillations prevail

New algorithms show accuracy, reliability in gauging unconsciousness under general anesthesia

May 6, 2021
Research Findings
Machine learning software advances could help anesthesiologists optimize drug dose

Anesthesia doesn't simply turn off the brain, it changes its rhythms

April 27, 2021
Research Findings
Simultaneous measurement of neural rhythms and spikes across five brain areas in animals reveals how propofol induces unconsciousness