Neurons glow green against a black background in a section of a mouse brain. A few red specks can be seen. An inset magnifies one of these cells that has red and green staining.
April 28, 2025
Dopamine signals when a fear can be forgotten
A 2 by 2 array of panels that each show a hairpin-like shape of blue stained cells. The left column is laberled "Ambient light/sound." The right column is labeled "40Hz Stimulation." The panels in the 40Hz column show more yellow arrows pointing white blotches than the panels in the ambient column.
April 24, 2025
In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity
Emery Brown sits behind his desk in his MIT office. A teddy bear rests nestled among some books on a shelf behind him, just over his right shoulder.
April 21, 2025
In kids, EEG monitoring of consciousness safely reduces anesthetic use
In a grayscale image a wiggly worm is seen in a vertical orientation above a lumpy background of bacteria
April 8, 2025
A simple animal’s response to sickness highlights the nervous system’s surprising degrees of flexibility
A black brain shown in a side view glows blue. The amygdala, a small almond-shaped structure toward the bottome center stands out especially. In the background there are theater masks signifying emotions.
April 7, 2025
Molecules that fight infection also act on the brain, inducing anxiety or sociability

New grant to study possibility of an immunotherapy for autism

November 2, 2023
New Research
Picower Institute-based collaboration will study mechanisms that might enable peripheral immune cells to deliver a potentially therapeutic molecule to the brain.

Aging Brain Initiative symposium showcases ‘cutting edge’ research across MIT

November 1, 2023
Picower Events
Seed projects, posters represent a wide range of labs working on technologies, therapeutic strategies, and fundamental research to advance understanding of age-related neurodegenerative disease

Anesthesia technology precisely controls unconsciousness in animal tests

October 31, 2023
Research Findings
An advanced closed-loop anesthesia delivery system that monitors brain state to tailor propofol dose and achieve exactly the desired level of unconsciousness could reduce post-op side effects

Mark Bear wins SfN’s Julius Axelrod Prize

October 30, 2023
Picower People
Society for Neuroscience Award recognizes Professor Mark Bear’s synaptic plasticity research, its translation to potential amblyopia and autism treatments, and his career of mentorship.

A multifunctional tool for cognitive neuroscience

October 20, 2023
Research Findings
A flexible new tool both monitors and manipulates neural activity in the brains of large animals.

Morgan Sheng among 12 with MIT ties elected to the National Academy of Medicine for 2023

October 10, 2023
Picower People
Five MIT faculty, along with seven additional affiliates, are honored for outstanding contributions to medical research.

Decoding the complexity of Alzheimer’s disease

September 28, 2023
Research Findings
By analyzing epigenomic and gene expression changes that occur in Alzheimer’s disease, researchers identify cellular pathways that could become new drug targets

Study shows how a single neuron’s parallel outputs can coordinate many aspects of behavior

September 27, 2023
Research Findings
In C. elegans worms, a single neuron named HSN uses multiple chemicals and connections to orchestrate egg-laying and locomotion over the course of several minutes

Resolving a seeming contradiction, study advances understanding of visual recognition memory

September 27, 2023
Research Findings
Scientists have invested decades in piecing together how our vision is so good at recognizing what’s familiar. A new study overcomes an apparent discrepancy in data to reveal a new insight into how it works.

Individual neurons mix multiple RNA edits of key synapse protein, fly study finds

September 18, 2023
Research Findings
Neurons stochastically generated up to eight different versions of a protein regulating neurotransmitter release, which could vary how they communicate with other cells

The Sleeping Brain

September 14, 2023
Neural activity during sleep has a signature structure that the brain uses to make profound improvements in our thinking and wellness

Study decodes surprising approach mice take in learning

September 14, 2023
Research Findings
Neurotypical humans readily optimize performance in ‘reversal learning’ games, but while mice learn the winning strategy, they refuse to commit to it, a new study shows. The research provides a mathematical way to track the rodents’ more mixed tactics