A portrait of Mriganka Sur

Mriganka Sur

Newton Professor of Neuroscience
Investigator in The Picower Institute for Learning and Memory
Director, Simons Center for the Social Brain
Professor, Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology

Contact Info

Office: 46-6237
Phone: 617-253-8784
Email: msur@mit.edu

Administrative Assistant

Alexandra Sokhina
Office: 46-6223
Phone: 617-324-7757

The Sur laboratory develops novel experimental and computational methods for analyzing brain activity, and uses them to study the development, plasticity and dynamics of circuits in the cerebral cortex of the brain.

The developing brain requires a genetic blueprint but is also acutely sensitive to experience and the environment. The brain is shaped by learning and memory, and its function is importantly modulated by internal states such as attention, through dynamic changes in information transmission and processing.

Brain processing is enabled by circuits comprised of excitatory and inhibitory neurons along with astrocytes, which are wired during development by mechanisms of plasticity and change during adulthood by mechanisms of learning and memory. Abnormal wiring of synapses and circuits lies at the core of many brain disorders.

The goal of our laboratory is to define rules of synaptic and circuit plasticity in the developing cortex, and dynamics of activity in the adult cortex during information processing and learned behavior. We aim to utilize this understanding to discover mechanisms of brain disorders and propose novel therapeutics.

Our laboratory studies these topics using state-of-the-art techniques. These include novel approaches for recording the activity and analyzing the function of neurons, astrocytes, synapses and circuits of the cerebral cortex in vivo and in vitro, combined with molecular approaches to study synaptic plasticity and computational approaches to study information processing and dynamics.

Our research is funded by grants from the National Institutes of Health [BRAIN Initiative, NEI, NINDS, NIMH], the National Science Foundation, the Multi-University Research Initiative (MURI), and the Simons Foundation.

Dr. Mriganka Sur is the Newton Professor of Neuroscience in The Picower Institute for Learning and Memory and Director of the Simons Center for the Social Brain at MIT, which he founded after 15 years as head of the MIT Department of Brain and Cognitive Sciences. Dr. Sur studies the organization, plasticity and dynamics of the cerebral cortex of the brain using experimental and theoretical approaches. He has discovered fundamental principles by which networks of the cerebral cortex are wired during development and change dynamically during learning. His laboratory has identified gene networks underlying cortical plasticity, and pioneered high resolution imaging methods to study cells, synapses and circuits of the intact brain. His group has demonstrated novel mechanisms underlying disorders of brain development, and proposed innovative strategies for treating such disorders. His laboratory has discovered core functional rules of inhibitory-excitatory neuronal circuits in the cerebral cortex, and revealed dynamics of information processing across widespread cortical areas. The impact of these discoveries, which answer long-standing questions about computations underlying learning, decision-making and perception-action transformations, ranges from understanding dysregulation in brain disorders to brain architectures for next-generation AI.

Dr. Sur received the B. Tech. degree in Electrical Engineering from the Indian Institute of Technology, Kanpur, and the PhD degree in Electrical Engineering from Vanderbilt University, Nashville. He has received numerous awards and honors, most recently the Krieg Cortical Discoverer Prize, and delivered distinguished lectures world-wide. He has trained over 80 doctoral students and postdoctoral fellows, and received awards for outstanding teaching and mentoring. At MIT, he has been recognized with the Sherman Fairchild and Newton Chairs. He is an elected Fellow of the Royal Society of the UK, the National Academy of Medicine, the American Academy of Arts and Sciences, the American Association for the Advancement of Science, the World Academy of Sciences, the Indian National Science Academy, and the American Institute of Medical and Biological Engineering.

  • Charles Judson Herrick Award, American Association of Anatomists
  • Sigma Xi Distinguished Lecturer
  • Distinguished Alumnus Award, Indian Institute of Technology, Kanpur
  • Elected Fellow, American Academy of Arts and Sciences
  • Elected Fellow of the Royal Society, UK
  • Society for Neuroscience Special Lecture
  • Elected Fellow, Third World Academy of Sciences/Academy of Sciences of the Developing World
  • Elected Member, Institute of Medicine of the National Academies, USA
  • Distinguished Alumnus Award in the Psychological Sciences, Vanderbilt University
  • Elected Fellow, American Institute of Medical and Biological Engineering
Featured publications are below. For a full list visit the lab website linked above.

July 3, 2018
Pho GN, Goard MJ, Woodson J, Crawford B, Sur M. Nature Communications (2018) 9:259
June 22, 2018
El-Boustani S, Ip JPK, Breton-Provencher V, Knott GW, Okuno H, Bito H, Sur M. Science 360, 1349–1354 (2018)
May 8, 2018
Ip JP, Mellios N, Sur M. Nature Reviews Neuroscience 19:368-382, 2018.
April 18, 2018
Ip JP, Nagakura I, Petravicz J, Wiemer EAC, Sur M. The Journal of Neuroscience 38:3890-3900, 2018.
April 25, 2017
Mellios, N., D.A. Feldman, S.D. Sheridan, J.P.K. Ip, S. Kwok, S.K. Amoah, B. Rosen, B.A. Rodriguez, B. Crawford, R. Swaminathan, S. Chou, Y. Li, M. Ziats, C. Ernst, R. Jaenisch, S.J. Haggarty, and M. Sur. Molecular Psychiatry [doi: 10.1038/mp.2017.86], 2017.

How the brain responds to surprising events

June 1, 2022
Research Findings
Unexpected outcomes trigger release of noradrenaline, which helps the brain focus its attention and learn from the event

Circuit that focuses attention brings in wide array of inputs

April 21, 2022
Research Findings
With a comprehensive map of the wiring, researchers can now discern what information flows into the circuit to enable a key brain function

The model remodeler

March 14, 2022
Research Feature
A Picower Institute primer on ‘plasticity,’ the brain’s amazing ability to constantly adapt to and learn from experience

Mriganka Sur elected to the 2022 class of the AIMBE College of Fellows

February 28, 2022
Picower People
National Institute recognizes innovations and research elucidating neuronal plasticity and computations

'Risky' Research

December 20, 2021
Research Feature
How bold new neuroscience research projects get off the ground

'What Were you Thinking?'

September 20, 2021
Research Feature
How brain circuits integrate many sources of context to flexibly guide behavior

Behind the scenes, brain circuit ensures vision remains reliable

September 8, 2021
As mice watched movies, scientists watched their brains to see how vision could be represented reliably. The answer is that consistency in representation is governed by a circuit of inhibitory neurons

Grant to help scientists test whether brain region is a key locus of learning

July 23, 2021
New Research
Long thought of as a generic alarm system, the locus coeruleus may actually be a sophisticated regulator of learning and behavior, an MIT team posits

In ‘minibrains,’ hindering key enzyme by different amounts has opposite growth effects

May 10, 2021
Research Findings
Surprising findings can help improve organoid cultures, explain role of GSK3-beta in brain development

Tiny brains grown in 3D-printed bioreactor

April 7, 2021
Research Findings
Small device contains wells to let small bits of tissue grow, develop, and be studied in real time

Elie Adam    
Postdoctoral Fellow

Vincent Breton-Provencher
Postdoctoral Fellow

Chloé Delepine
Postdoctoral Fellow

Tudor Dragoi
Research Support Associate

Gabrielle Drummond
Graduate Student

Karen Guadalupe Cruz
Graduate Student, BCS

Ming Hu    
Postdoctoral Associate

Rafiq Huda    
Postdoctoral Associate

Pak Kan Ip    
Postdoctoral Fellow

Taylor Johns
Technical Associate

Nhat Minh Le
Graduate Student

Ning Leow
Graduate Student

Keji Li    
Postdoctoral Fellow

Marvin Nayan
Postdoctoral Fellow

Vincent Pham    
Technical Associate

Eleana Ricci
Program Administrator, SBCS

Jitendra Sharma    
Research Scientist

Jennifer Shih
Postdoctoral Fellow

Grayson Oren Sipe    
Postdoctoral Fellow

Hiroki Sugihara    
Research Scientist

Austin Sullins  
Technical Associate

Xin Tang    
Research Affiliate

Hayley Tsang  
Postdoctoral Fellow

Katya Tsimring
Graduate Student

Murat Yildirim    
Postdoctoral Associate