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… how a rare gene variant contributes to Alzheimer’s disease Lipid metabolism and cell membrane function can be disrupted in the … a protein that transports lipids across cell membranes. Lipid metabolism is also the primary target of a more common … how a rare gene variant contributes to Alzheimer’s disease lipid metabolism neurodegeneration epigenetics mRNA dementia …

… gene enhances Alzheimer’s risk The gene variant disrupts lipid metabolism, but in cell experiments the effects were reversed … Narayan, and current MIT postdoc Julia Maeve Bonner. Lipid dysregulation The human gene for APOE, or … risk neurodegeneration Cellular and Molecular ApoE lipid metabolism Alzheimer's Disease Glia Tissue Processing …

… Rhythms , Neuroimmune interactions , myelination , ApoE , lipid metabolism , Neuronal DNA damage Contact Info Office: 46-4235 …  leads to expression differences for genes associated with lipid metabolism and storage. In follow-up studies using our … Brain Rhythms Neuroimmune interactions myelination ApoE lipid metabolism Neuronal DNA damage …

… one copy of the APOE4 gene. APOE is a protein involved in lipid transport. Studies show that the APOE4 variant is … pathway, which showed that APOE4-induced dysfunction of lipid metabolism in neurons by cellular accumulation of unsaturated …