August 08, 2017
Blocking a key enzyme may reverse memory loss
… the enzyme that forms the blockade. The enzyme, known as HDAC2, turns genes off by condensing them so tightly that … The MIT team has now found a way to precisely target HDAC2, by blocking its interaction with a binding partner … the first time we have found a specific mechanism by which HDAC2 regulates synaptic gene expression,” says Li-Huei Tsai, …