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HDAC2 Inhibition

Blocking a key enzyme may reverse memory loss

August 08, 2017

… approach to developing treatments for Alzheimer’s disease. HDAC2 Sp3 treatment epigenetics … the enzyme that forms the blockade. The enzyme, known as HDAC2, turns genes off by condensing them so tightly that … The MIT team has now found a way to precisely target HDAC2, by blocking its interaction with a binding partner …

Epigenetic loss and rescue of memory recall

… untreated mice could not. In 2009 her group identified HDAC2 as the specific HDAC enzyme that regulated neuronal … supporting synaptic plasticity, learning, and memory. HDAC2 was the target of the effective inhibitors. WT, or … or synapses, on the dendrites of their neurons. If HDAC2 is knocked out (KO) they produce many more (see …

Memory and its meaning

October 07, 2019

… visual cortex prefrontal cortex working memory epigenetics HDAC2 replay Lest anyone forget, in 1994 when MIT launched a … their understanding. In 2009, they determined that HDAC2 was the specific HDAC responsible and in 2012 they showed that Alzheimer’s pathology misregulates HDAC2, indicating one way the disease disrupts memory. In …