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Genome-wide genetic screening in the mammalian brain

… study published in Neuron in January 2020, Myriam Heiman ’s team at The Picower Institute and the Broad Institute came … striatum of the mouse brain, a brain region implicated in Huntington’s disease, Parkinson’s disease, and various neuropsychiatric …

Aging Brain Initiative symposium showcases ‘cutting edge’ research across MIT

November 01, 2023
… to advance understanding of age-related neurodegenerative disease dementia neurodegeneration aging epigenetics Seed … neuroscience, and other disciplines, presenters at MIT’s Aging Brain Initiative Symposium Oct. 23 delivered a rich … region called the striatum. She gave an example of work on Huntington’s disease, a neurodegenerative disease of aging. …

Life and death factors for neurons

… factors for neurons Discoveries Diseases such as Alzheimer’s, Parkinson’s, ALS and Huntington’s are “neurodegenerative” because over time more … cells in people with the mutation that causes Huntington’s disease, Heiman’s lab devised a novel way, called “SLIC,” of …

TRAP

… the activity of particular cell types, such as studies of Huntington’s disease in which striatal neurons degenerate. TRAP works by …
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