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Morgan Sheng

… other serious mental illnesses. Parkinson's disease Glia synaptic plasticity neurodegeneration therapeutics psychiatric … focused on the molecular cellular biology of synapses and synaptic plasticity, and pathogenic mechanisms of …

How brain cells pick which connections to keep

August 06, 2019

… synapse formation synapse assembly synapse disassembly synaptic plasticity CPG15 PSD multiphoton microscopy … excitatory synapses are formed, and the recruitment of the synaptic scaffold, PSD95, that signals that a synapse is …

Study shows how specific gene variants may raise bipolar disorder risk

January 09, 2019

… diagnosis Bipolar Disorder synapse function CPG2 candidate plasticity genes plasticity genes plasticity … bipolar disorder was CPG2 significantly lower. Other key synaptic proteins were not uniquely lower in bipolar … BD disrupt the levels and function of a protein crucial to synaptic activity and therefore the health of neural …

HDAC2 Inhibition

… regulating the expression of neuronal genes supporting synaptic plasticity, learning, and memory and as the target of the … A schematic of how blocking HDAC2 or SP3 can restore synaptic function and memory. …

Treating Amblyopia

… another problem that deprives an eye of clear sight, the synaptic connections from the affected eye are weakened in … 8. Through decades of study of the fundamental workings of synaptic plasticity, Mark Bear has helped to discover that the …

Study probing visual memory, amblyopia unveils many-layered mystery

December 13, 2019

… many-layered mystery December 13, 2019 Research Findings Plasticity underlying amblyopia found in visual cortex layer … visual cortex to make the circuit connection changes, or “plasticity,” necessary for both visual recognition memory and … in stimulus-selective response potentiation, or SRP, the synaptic change believed to give rise to visual recognition …

How synapses change

… the brain flexible and adaptable (a property called “plasticity”). If it weren’t, we couldn’t learn or remember … are built to change and how both the “pre-” and “post-” synaptic sides of a synapse interact to set plasticity in motion. In 2005, for example, Littleton and lab …

Colloquium on the Brain and Cognition with Daniel Colón-Ramos, PhD, "Powering the Nervous System: Energy Distribution in the Connectome"

… in a functional connectome, much like the structure of synaptic positions in an anatomical connectome, represents a … shapes information flow and circuit function, including plasticity. To address this hypothesis it is necessary to … enzymes are organized within polarized neurons to support synaptic function, 2) How glycolytic energy states within …

Brain networks encoding memory come together via electric fields, study finds

July 10, 2023

… mathematically s how how electric fields arise from synaptic activity, how synaptic activity changes over time and is influenced by … of the circuits they form, a phenomenon called synaptic plasticity. Clinical technologies such as transcranial …

MIT Colloquium on the Brain and Cognition with Betty Hong, PhD, Caltech

… Circuits Neuro Genomics and Proteomics Optogenetics Neural Plasticity Public Event MIT Colloquium on the Brain and … of neuronal activity-regulated gene expression in synaptic development, with a particular focus on the … Wilson at Harvard Medical School, Betty worked on the synaptic and circuit mechanisms underlying early stages of …