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Study finds circular RNA helps drive brain development

October 16, 2025
… Findngs Study finds circular RNA helps drive brain development MIT neuroscientists show in a new study that … neurons build circuit connections, or synapses, during the development of the visual system in young mice. Wiring up the … interfering with circHomer1 not only undermined the normal development of synapses, but also delayed visual system …

The Developing Brain

July 11, 2018
… to understand how experience and deprivation modify the development of the cortex and are at a point where we think … happening, Nedivi said, but it is most prominent during development. Many capabilities such as language, vision, or … an example of how curiosity about fundamental aspects of development can lead to discoveries relevant to human health. …

‘SCOUT’ helps researchers find, quantify significant differences among organoids

December 08, 2020
… experimentally manipulable models of human neurological development and disease, but not without confounding … the team reports new patterns of disruption in organoid development from Zika virus infection, providing new insights … is essential to accelerate the pace of discovery and the development of therapeutic strategies,” said Chung, an …

In ‘minibrains,’ hindering key enzyme by different amounts has opposite growth effects

May 10, 2021

Advanced imaging reveals mired migration of neurons in Rett syndrome lab models

July 29, 2022
… in Rett syndrome lab models Using organoids to model early development, researchers used an emerging microscopy … how the mutation affects the early stages of human brain development, researchers in the lab Mriganka Sur , Newton … Then the team led by postdoc Murat Yildirim examined the development of each type of minibrain using an advanced …

In Down syndrome cells, genome-wide disruptions mimic a senescence-like state

January 06, 2022
… the architecture of all of a cell’s chromosomes during development.” Above: Neural progenitor cells with the typical … important differences in cell function that affect brain development. Treated as senescence For the first couple of … are not appropriate for attempting to intervene in brain development amid Down syndrome, Meharena said. Instead an …

MIT Team Reveals What Happens to Brain Immune Cells During Alzheimer’s Development

December 07, 2017
… What Happens to Brain Immune Cells During Alzheimer’s Development Alzheimer's News Today reports on new findings … What Happens to Brain Immune Cells During Alzheimer’s Development Alzheimer's Disease …

Grant fuels effort to develop new Alzheimer’s drug

May 22, 2020
… this data, the NDC collaborators, including Ray’s drug development team, have been pursuing the hypothesis that …

Beckman Foundation Names Mark Bear as 2018 Beckman-Argyros Vision Research Award Winner

August 07, 2018
… breakthroughs in vision research; particularly through the development of an innovative technology or fundamental … circumstances in animal models, raising hope for development of new approaches to cure amblyopia, even in … of sensory input and has the potential to accelerate the development of novel therapeutic interventions for treatment …

Connect or reject: Extensive rewiring builds binocular vision in the brain

July 01, 2025
… neurons add and shed synapses at a frenzied pace during development to integrate visual signals from the two eyes. … days in the same live mouse through a critical period of development, to ask, what happens to the synapses or spines … a spine was, the more likely it was to be retained during development.” The researchers also noticed another trend. …

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Massachusetts Institute of Technology
43 Vassar Street, Bldg. 46-1303
Cambridge, MA 02139
(+1) 617-324-0305
(+1) 617-452-2588

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