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… August 6, 2019 Research findings Novel study shows protein CPG15 acts as a molecular proxy of experience to mark … synapse assembly synapse disassembly synaptic plasticity CPG15 PSD multiphoton microscopy … MIT neuroscientists have identified the gene and protein, CPG15, that allows experience to tap a synapse as a keeper. …

… discovering that mice lacking a synaptic protein called CPG15 were slow learners , Nedivi hypothesized that it was … test that , her lab exposed normal mice and others lacking CPG15 to stretches of time in the light, when they could gain … in those synapses in normal mice and the ones without CPG15 . They found that CPG15 helped experience make synapse …

… Disorder amblyopia Rett syndrome Cdk5 LTD MECP2 CPG2 CPG15 Developing minds are naturally curious, and many … focused on two that had not been studied before: CPG2 and CPG15. “We’ve basically followed them where they took us,” Nedivi said. She’s shown that CPG15 encodes an extracellular signaling molecule that …

… much about how the brain works more broadly CPG15 multiphoton microscopy LTD amblyopia autism IGF1 Rett … the protein of a plasticity gene she has long studied, CPG15, represents experience to make a newly formed synapse … in a circuit responding to experience, it expresses CPG15 and that’s what recruits another protein called PSD95 …

… mechanisms that enable the brain to adapt to experience CPG15 candidate plasticity genes CPG2 multiphoton microscopy …

… synaptic function of two previously unknown CPGs: CPG2 and CPG15. In a study published earlier this year, her lab showed …