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Frontiers in Neurotechnology

… cell types with light, observe activity of thousands of cells in a living brain, and interrogate fine molecular and … Furthermore, we can grow mini brains derived from patient cells to study human-specific disease mechanisms. The Picower … Organizer Email bgreeno@mit.edu Small Image in Place of Hero Off …

Three from MIT elected to the National Academy of Sciences

May 01, 2019

… molecular circuitry that governs the function of mammalian cells in health and disease and has pioneered many leading … international scientific community. 147 30 Small Image in Place of Hero On List on Aging Brain Initiative Page On List …

Breaking DNA in health and disease

… mechanism that helps neurons form memories in the first place. In studying mice modeling Alzheimer’s, Tsai’s lab … realized, not only in neurons but also in other brain cells called glia. …

Molecular Replacement

… and express an inserted version in precisely targeted cells. This allowed them to quickly and precisely alter a … Because of the use of a virus to alter DNA in post-mitotic cells, this technique allowed the interrogation of molecular … of structure and function within finely targeted cells or brain regions. The technique has become one in which …

Kay Tye improvises to understand our inner lives

October 04, 2017

… findings — which come in large part from tweaking nerve cells, and behaviors, in lab animals — have led to a deeper … After a series of experiments on how certain nerve cells respond to cocaine, the data were in shambles. But Tye … the mice didn’t seem to like the sensation, avoiding a place where the stimulation happened, the artificial kick …

As brain extracts meaning from vision, study tracks progression of processing

July 10, 2018

… to a specific understanding relevant to behavior, brain cells in each of six cortical regions operated along a … task, too. Few neuroscientists would be surprised that V4 cells were particularly active for color sensation while MT … Grant EXC 307). 44 23 7 3 241 15 Small Image in Place of Hero Off List on Aging Brain Initiative Page Off …

SCOUT

… to culture cerebral organoids, or “minibrains,” using stem cells derived from people has given scientists experimentally … recognize and track architectural patterns formed by the cells as the organoids develop or are affected in models of …

Aging Brain Seminar with Andrew S. Yoo, PhD, Washington University School of Medicine

… generate human neurons by directly converting non-neural cells like fibroblasts. We use this approach to model aging … Off On Organizer Email bgreeno@mit.edu Small Image in Place of Hero Off …

The Sleeping Brain

September 14, 2023

… chemical called adenosine builds up. When that binds to cells in the POA, it inhibits arousal circuits and promotes … lab reported new evidence from mice that while some “place cell” neurons in the hippocampus quickly encode a basic … that, too. 39 49 1102 13 12 241 20 15 22 8 Small Image in Place of Hero Off List on Aging Brain Initiative Page Off …

Fundamental questions find advanced answers, approaches at Fall Symposium

October 18, 2019

… new connections to later be discarded or cemented, and how cells appear to fleetingly form inhibitory synapses next to … In recent research, his team has been able to track how cells in the supramammillary nucleus of the hypothalamus … 2 45 49 15 20 23 32 16 27 8 3 7 22 28 Small Image in Place of Hero Off List on Aging Brain Initiative Page Off …