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Epigenetic loss and rescue of memory recall

IGF1

… of Rett Syndrome cases. Years of basic research on genes involved in synaptic plasticity led Mriganka Sur ’s lab to discover that in mouse … and circuit-specific problems in the maturation and plasticity of cortical neurons. The dysfunction, which …

Study reveals a protein’s key contribution to heterogeneity of neurons

November 29, 2021

… in which neurons communicate in circuits, but also their “plasticity,” or ability to change those connections when new … change how some neurons communicate and implement plasticity. The team found that expression of the tomosyn … when receptors across the synapse begin to falter, a plasticity known as presynaptic homeostatic potentiation …

Special Seminar with Mriganka Sur, PhD

… Autism Spectrum Disorders Public Event Title: "Cortical Plasticity" This is a Zoom webinar. Click here to join or … into your browser: https://mit.zoom.us/j/97608996526 Plasticity shapes the brain during development, and … synapses. Alongside, it is increasingly clear that risk genes associated with neurodevelopmental disorders …

Seemingly similar, two neurons show distinct styles as they interact with the same muscle partner

July 07, 2020

… innervate reveal distinct propensities for change, or “plasticity” drosophila synapse function synaptic plasticity … to respond to changes, a key property known as “synaptic plasticity.” Synaptic plasticity is considered an essential …

Study finds ‘volume dial’ for turning neural communication up or down

May 06, 2020

… synapses synapse function synaptic transmission synaptic plasticity drosophila … activity in a circuit, a property called “synaptic plasticity.” Mónica C. Quiñones-Frías describes key … manner and can act as a switch for short term synaptic plasticity,” Quiñones-Frías said. Research scientist Yulia …

Mechanisms and therapeutics for Rett Syndrome

… or synapses, to change with experience (a property called “plasticity”), the lab of Mriganka Sur, Newton Professor of … last year. The lab discovered the role of IGF1 in neural plasticity in 2006 when they showed that it critically … left open (a dramatic phenomenon called ocular dominance plasticity). In 2009 they revealed that IGF1 was also …

Memory making involves extensive DNA breaking

July 06, 2021

… breaking July 6, 2021 Research Findings To quickly express genes needed for learning and memory, brain cells snap both … To quickly express genes needed for learning and memory, brain cells snap both … change their connections (a phenomenon called “synaptic plasticity”) and memories are formed when groups of neurons …

CPG15 (“Neuritin”)

… allowing us to adapt to and learn from experience. This “plasticity” requires not only the flexibility to remove or … with consequential roles in activity-dependent neural plasticity. In several papers since, she has discovered …

How brain cells pick which connections to keep

August 06, 2019

… formation synapse assembly synapse disassembly synaptic plasticity CPG15 PSD multiphoton microscopy … to all other molecules that are involved in synaptic plasticity.” A new model and method In all, the paper’s data …