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With these neurons, extinguishing fear is its own reward

January 15, 2020

… also form new memories to suppress fearful ones amygdala engram … stained green, while the cells in a fear extinction memory engram appear red. Overriding fear with reward In a prior … population that holds specific memory information, memory “engram” cells. Zhang labeled Ppp1r1b neurons that were …

Brain networks encoding memory come together via electric fields, study finds

July 10, 2023

… multiple brain regions to form a memory network, or “engram.” They therefore broadened their analyses to look at … information across both regions, unifying them into an engram memory network. Further clinical implications …

Emotions and Memory

… ensemble of neurons that encoded the memory (called an “engram) and engineered them to be controllable with flashes … called “optogenetics”). Then, when they reactivated the engram of that context while presenting a reward, the cells … The researchers also did the opposite, swapping an engram’s positive association for a fearful one. A year later …

Memory and its meaning

October 07, 2019

… they could pinpoint the ensemble of a hippocampal “engram,” the neurons that encoded a specific fear memory. How … created a false memory by artificially reactivating the engram of a previously experienced place while giving the … conditioning fear. But then, when they reactivated the engram of that context while presenting a reward, the cells …

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With these neurons, extinguishing fear is its own reward

Brain networks encoding memory come together via electric fields, study finds

Emotions and Memory

Memory and its meaning

Scientists identify neurons devoted to social memory

How we recall the past

Susumu Tonegawa

Picower Fellows alumni

Genes & plasticity in memory

Celebrating 20 years of discovery, Picower Institute looks ahead to continuing impact