Research Topics

As this gallery of featured people and projects illustrates, Picower Institute scientists study brain structure and function at scales from genes and molecules to cells, circuits and regions. They also study the behaviors and cognitive processes that result, and seek to uncover how disruptions at different scales can result in developmental, psychiatric or neurodegenerative disorders. They employ—and often invent—the newest technologies in their work. To learn more about any of these specific areas, click "Research Topics" above, select areas of interest, and you'll find relevant Picower people, discoveries and events.

The way sensory prediction changes under anesthesia tells us how conscious cognition works

October 7, 2024
Research Findings
New study adds evidence that consciousness requires communication between sensory and cognitive regions of the brain’s cortex

Research quantifying “nociception” could help improve management of surgical pain

September 23, 2024
Research Findings
New statistical models based on rigorous physiological data from more than 100 surgeries provide objective, accurate measures of “nociception,” the body’s subconscious perception of pain.

Better living through brain chemistry

September 6, 2024
Research Feature
Studying neuromodulators such as serotonin and norepinephrine could help make them better targets for psychiatric or psychedelic drugs

Study assesses seizure risk from stimulating thalamus

August 21, 2024
Research Findings
In awake mice, researchers found that even low stimulation currents could sometimes still cause electrographic seizures

Study reveals ways in which 40Hz sensory stimulation may preserve brain’s ‘white matter’

August 8, 2024
Research Findings
MIT scientists report that gamma frequency light and sound stimulation preserves myelination in mouse models and reveal molecular mechanisms that may underlie the benefit.

Study across multiple brain regions discerns Alzheimer’s vulnerability and resilience factors

July 24, 2024
Research Findings
Genomics and lab studies reveal numerous findings, including a key role for Reelin amid neuronal vulnerability, and for choline and antioxidants in sustaining cognition.

HHMI honor will advance Flavell’s studies of how internal brain states arise and affect behavior

July 23, 2024
Picower People
In animals from worms to humans, feelings and drives such as hunger or sleepiness influence behavior. With flexible, long-term support as a newly named HHMI Investigator, Steve Flavell will advance his lab’s studies of exactly how that happens.

Study reveals how an anesthesia drug induces unconsciousness

July 15, 2024
Research Findings
Propofol, a drug commonly used for general anesthesia, derails the brain’s normal balance between stability and excitability.

Pew award will fund study of neural role in respiratory disease

June 18, 2024
Picower People
As a newly named Pew Biomedical Scholar, Assistant Professor Sara Prescott and her lab plan to test whether and how neurons have a role in airway remodeling, which goes awry in many diseases.

Technologies enable 3D imaging of whole human brain hemispheres at subcellular resolution

June 13, 2024
Research Findings
A suite of three innovations by an MIT-based team enables high-throughput imaging of human brain tissue at a full range of scales and mapping connectivity of neurons at single cell resolution.

Consciousness

June 12, 2024
Research Feature
Emerging evidence shows how brain waves help to knit our internal thoughts and external awareness together into an organized, unified whole

With programmable pixels, novel sensor improves imaging of neural activity

June 7, 2024
Research Findings
New camera chip design allows for optimizing each pixel’s timing to maximize signal to noise ratio when tracking real-time visual indicator of neural voltage